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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Influence of Oscillatory Mixing on the Injectability of Three Acrylic and Two Calcium-Phosphate Bone Cements for Vertebroplasty
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Influence of Oscillatory Mixing on the Injectability of Three Acrylic and Two Calcium-Phosphate Bone Cements for Vertebroplasty

机译：振荡混合对三种丙烯酸和两种磷酸钙骨水泥对椎体成形术可注射性的影响

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摘要

Injecting acrylic and, increasingly, calcium-phosphate cements into the porous bone structure is an emerging procedure, referred to as vertebroplasty, for the augmentation of osteoporotic vertebrae. Despite the benefits of vertebroplasty, it has limitations. The limitations of interest in this study are the injectability of bone cements and their mixing variability (i.e., low reproducibility of resulting viscosity). The objective of this study is to investigate the effect of oscillatory versus manual mixing on cement viscosity and mixing variability. Five cements are tested: (a) Vertebroplastic~(TM), (b) DP-Pour~(TM), (c) Antibiotic Simplex~R, (d) chronOS Inject~(TM), and (e) Biopex~(TM). Compared to manual mixing, oscillatory mixing significantly decreased the mean viscosity and the mixing variability, which was inferred from the coefficient of variation. For example, under oscillatory mixing, the viscosity and the variability for Vertebroplastic decreased to one-third of the corresponding values for manual mixing. Similar results were obtained for the other cements. The decrease in viscosity is attributed to the pseudo-plastic behavior of bone cements. The decrease in the variability of cement viscosity was attributed to greater dispersive mixing of the cement components under oscillatory mixing. The decrease in viscosity eases the injection by reducing the pressure required. The decrease in the variability of cement viscosity increases reproducibility of the cement injection. Oscillatory mixing appears to have the potential to contribute to improving vertebroplasty.
机译：将丙烯酸和越来越多的磷酸钙水泥注入多孔骨结构中是一种新兴的手术，称为椎体成形术，用于增强骨质疏松椎骨。尽管椎骨成形术有好处，但它有局限性。该研究中感兴趣的局限性是骨水泥的可注射性及其混合变异性（即所得粘度的低再现性）。这项研究的目的是研究振荡混合与手动混合对水泥粘度和混合变异性的影响。测试了五种水泥：（a）VertebroplasticTM，（b）DP-PourTM，（c）抗生素Simplex®R，（d）chronOS InjectTM，和（e）Biopex〜（ TM值）。与手动混合相比，振荡混合显着降低了平均粘度和混合变异性，这是由变异系数推断出来的。例如，在振荡混合下，椎骨塑料的粘度和变异性降低到手动混合相应值的三分之一。对于其他水泥也获得了类似的结果。粘度的降低归因于骨水泥的假塑性行为。水泥粘度变化性的降低归因于在振荡混合下水泥组分的更大的分散混合。粘度的降低通过降低所需的压力使注射容易。水泥粘度变化性的降低提高了水泥注入的重现性。振荡混合似乎有可能有助于改善椎体成形术。

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