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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >New injectable and radiopaque antibiotic loaded acrylic bone cements.
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New injectable and radiopaque antibiotic loaded acrylic bone cements.

机译：新型可注射且不透射线的抗生素加载的丙烯酸骨水泥。

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The use of antibiotic loaded bone cements (ALBCs) has become a common clinical practice in the prevention and treatment of prosthesis-related infections. However, due to antibiotic resistance, there is a general interest in broadening the antibacterial spectrum of currently used drugs. The aim of this work is to formulate ALBCs for specific use in vertebroplasty and kyphoplasty, and to study the effect of the addition of ciprofloxacin alone and in combination with vancomycin on some properties of the cement. The cements were formulated using bismuth salicylate as the radiopacifier. The setting properties, residual monomer content, release of antibiotics, rheological behavior, injectability, and mechanical properties of these formulations were studied. They showed long setting times and low curing temperatures. From the release studies, antibacterial properties are assumed because the concentration of released antibiotic was higher than the minimum effective. Although the experimental cements had slightly reduced mechanical properties, the other alterations shown were negligible.
机译：在预防和治疗与假体相关的感染中，使用抗生素加载的骨水泥（ALBC）已成为一种常见的临床实践。然而，由于对抗生素的抗性，人们普遍感兴趣的是拓宽当前使用的药物的抗菌谱。这项工作的目的是配制专门用于椎骨成形术和后凸成形术的ALBC，并研究单独添加环丙沙星和与万古霉素联合使用对水泥的某些性能的影响。使用水杨酸铋作为不透射线剂配制水泥。研究了这些制剂的凝结性能，残留单体含量，抗生素释放，流变行为，可注射性和机械性能。它们显示出长的凝固时间和低的固化温度。根据释放研究，假定抗菌特性是因为释放的抗生素浓度高于最低有效浓度。尽管实验用水泥的机械​​性能略有降低，但所示的其他变化可忽略不计。

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