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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Effect of porosity and pore size on microstructures and mechanical properties of poly-epsilon-caprolactone- hydroxyapatite composites.
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Effect of porosity and pore size on microstructures and mechanical properties of poly-epsilon-caprolactone- hydroxyapatite composites.

机译：孔隙率和孔径对聚ε-己内酯-羟基磷灰石复合材料微观结构和力学性能的影响。

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摘要

The influence of variant pore-size and porosity on the microstructure and the mechanical properties of poly-epsilon-caprolactone (PCL) and hydroxyapatite (HA) composite were examined for an optimal scaffold in bone tissue engineering. Three various amounts of sodium chloride (NaCl, as porogens) with two distinct particle size ranges (212-355 mum and 355-600 mum) were blended into PCL and HA mixture, followed by a leaching technique to generate PCL-HA scaffolds with various pores and porosity. The porosities of the scaffolds were correlated with the porogen size and concentration. The morphological properties of the resulting scaffolds were assessed by micro-computerized tomography (muCT), scanning electron microscopy (SEM), and energy dispersive X-ray analysis (EDX). Extensive PCL-HA pore interconnections with thinner pore walls were present in scaffolds with higher concentration (4:1 w/w) and larger particulate of porogen used in the fabrication process. Embedding of HA particles in the scaffold resulted in rough surfaces on the composites. Instron actuator testing indicated that the tensile strengths and Young's moduli of scaffolds were influenced by both the porosities and pore sizes of the scaffold. It was apparent that increasing the concentration of porogen compromised the mechanical properties; and a larger porogen particle size led to increased tensile strength but a reduction in Young's modulus. Overall, the data indicated that modification of the concentration and particle size of porogen altered the porous features and mechanical strength of HA-PCL scaffolds. This provided means to manipulate the properties of biocompatible cell-supporting scaffolds for use as bone graft substitutes.
机译：考察了不同孔径和孔隙率对聚ε-己内酯（PCL）和羟基磷灰石（HA）复合材料的微观结构和力学性能的影响，以确定其在骨组织工程中的最佳支架。将具有两种不同粒径范围（212-355微米和355-600微米）的三种不同量的氯化钠（NaCl，作为致孔剂）混合到PCL和HA混合物中，然后采用浸提技术生成具有各种不同含量的PCL-HA支架毛孔和孔隙率。支架的孔隙率与致孔剂的大小和浓度相关。通过微型计算机断层扫描（muCT），扫描电子显微镜（SEM）和能量色散X射线分析（EDX）评估所得支架的形态学特性。在制造过程中使用浓度较高（4：1 w / w）和较大的成孔剂颗粒的支架中，存在具有较薄孔壁的大量PCL-HA孔互连。 HA颗粒在支架中的嵌入导致复合材料表面粗糙。 Instron致动器测试表明，支架的抗张强度和杨氏模量受支架的孔隙率和孔径的影响。显然，增加致孔剂的浓度会损害其机械性能。较大的成孔剂颗粒尺寸导致拉伸强度提高，但杨氏模量降低。总体而言，数据表明，致孔剂浓度和粒径的改变改变了HA-PCL支架的多孔性和机械强度。这提供了操纵用作骨移植替代物的生物相容性细胞支持支架的性质的手段。

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