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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Morphological characteristics of total joint arthroplasty-derived ultra-high molecular weight polyethylene (UHMWPE) wear debris that provoke inflammation in a murine model of inflammation
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Morphological characteristics of total joint arthroplasty-derived ultra-high molecular weight polyethylene (UHMWPE) wear debris that provoke inflammation in a murine model of inflammation

机译：在小鼠炎症模型中，源自全关节置换术的超高分子量聚乙烯（UHMWPE）磨损碎片的形态特征

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It is recognized that the chronic inflammation in peri-prosthetic tissue that contributes to implant failure frequently is provoked by the presence of wear debris. Some wear debris is inevitable because of the nature of the prosthesis, but not all patients develop severe inflammatory responses. The precise factors that mediate the severity of tissue inflammation to wear debris has yet to be fully defined. Because wear debris retrieved from peri-prosthetic tissue consists of a heterogeneous mixture of materials with various sizes and shapes, this study evaluated the influence of two major physical aspects of ultra-high molecular weight polyethylene (UHMWPE) wear debris (shape and surface texture) using a model of tissue inflammation. UHMWPE debris particulates recovered from 50 peri-prosthetic tissue samples were examined by scanning electron microscopy and categorized into four groups based upon aspect ratio and surface texture of the material. The four groups were defined as: 1) smooth and globular, 2) smooth and fibular, 3) rough and globular, and 4)rough and fibular. Histological analysis and ELISA assays were conducted to evaluate variations in cellular responses and cytokine production between the groups. The strongest expression of tumor necrosis factor alpha and interleukin-1 beta was found in tissues exposed to UHMWPE debris with both a rough surface texture and fibular shape, and this response was significantly elevated over debris particles with a smooth surface texture and globular shape. The data suggest that both shape and texture influence the severity of specific inflammatory responses and that rough debris surface texture exerts a marked effect on adverse tissue responses when combined with particles that have a sharp, elongated shape.
机译：公认的是，假体周围组织中的慢性炎症常常是由于磨损碎片的存在而引起的，其经常导致植入失败。由于假体的性质，一些磨损碎片是不可避免的，但是并非所有患者都会出现严重的炎症反应。介导组织炎症至磨损碎片严重程度的确切因素尚未完全确定。由于从假体周围组织中回收的磨损碎片由各种尺寸和形状的异质材料混合物组成，因此本研究评估了超高分子量聚乙烯（UHMWPE）磨损碎片的两个主要物理方面（形状和表面纹理）的影响使用组织炎症模型。从50个假体周围组织样品中回收的UHMWPE碎片颗粒通过扫描电子显微镜检查，并根据材料的纵横比和表面纹理分为四类。将这四组定义为：1）光滑和球形，2）光滑和腓骨，3）粗糙和球形，以及4）粗糙和腓骨。进行组织学分析和ELISA测定以评估各组之间细胞应答和细胞因子产生的变化。在暴露于具有粗糙表面纹理和腓骨形状的UHMWPE碎片的组织中，发现了肿瘤坏死因子α和白介素-1β的最强表达，并且该响应明显高于具有光滑表面纹理和球状形状的碎片。数据表明形状和质地都会影响特定炎症反应的严重程度，并且粗糙的碎片表面质地在与具有尖锐，细长形状的颗粒结合时会对不良组织反应产生显着影响。

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