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首页> 外文期刊>Journal of orthopaedic research >Antioxidant Impregnated Ultra-High Molecular Weight Polyethylene Wear Debris Particles Display Increased Bone Remodeling and a Superior Osteogenic: Osteolytic Profile vs. Conventional UHMWPE Particles in a Murine Calvaria Model
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Antioxidant Impregnated Ultra-High Molecular Weight Polyethylene Wear Debris Particles Display Increased Bone Remodeling and a Superior Osteogenic: Osteolytic Profile vs. Conventional UHMWPE Particles in a Murine Calvaria Model

机译：抗氧化剂浸渍的超高分子量聚乙烯磨损碎片颗粒显示出增加的骨重塑和出色的成骨性：在鼠颅盖模型中，溶骨曲线与常规UHMWPE颗粒相比

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Periprosthetic osteolysis remains a major limitation of long-term successful total hip replacements with ultra-high molecular weight polyethylene (UHMWPE) bearings. As intra and extracellular reactive oxygen species are know to contribute to wear debris-induced osteoclastic bone resorption and decreased osteoblastic bone formation, antioxidant doped UHMWPE has emerged as an approach to reduce the osteolytic potential of wear debris and maintain coupled bone remodeling. To test this hypothesis in vivo, we evaluated the effects of crosslinked UHMWPE wear debris particles (AltrX), versus similar wear particles made from COVERNOX containing UHMWPE (AOX), in an established murine calvaria model. Eight-week-old female C57B/6 mice (n = 10/Group) received a pre-op micro-CT scan prior to surgical implantation of the UHMWPE particles (2mg), or surgery without particles (sham). Dynamic labeling was performed by intraperitoneal injection of calcein on day 7 and alizarin on day 9, and the calvaria were harvested for micro-CT and histology on day 10. Surprisingly, we found that AOX particles induced significantly more bone resorption (1.72-fold) and osteoclast numbers (1.99-fold) vs. AltrX (p < 0.001). However, AOX also significantly induced 1.64-fold more new bone formation vs. AltrX (p < 0.01). Moreover, while the osteolytic:osteogenic ratio of both particles was very close to 1.0, which is indicative of coupled remodeling, AOX was more osteogenic (Slope=1.13 +/- 0.10 vs. 0.97 +/- 0.10). Histomorphometry of the metabolically labeled undecalcified calvaria revealed a consistent trend of greater MAR in AOX vs. AltrX. Collectively, these results demonstrate that anti-oxidant impregnated UHMWPE particles have decreased osteolytic potential due to their increased osteogenic properties that support coupled bone remodeling. (C) 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
机译：假体周围的骨质溶解仍然是长期成功使用超高分子量聚乙烯（UHMWPE）轴承进行全髋关节置换的主要限制。由于已知细胞内和细胞外活性氧会导致磨损碎片引起的破骨细胞骨吸收并减少成骨细胞形成，因此抗氧化剂掺杂的UHMWPE已经成为减少磨损碎片的溶骨潜力并维持耦合的骨重塑的一种方法。为了在体内测试该假设，我们在已建立的鼠颅模型中评估了交联的UHMWPE磨损碎片颗粒（AltrX）与由含UHMWPE（AOX）的COVERNOX制成的类似磨损颗粒的效果。八周大的雌性C57B / 6小鼠（n = 10 /组）在手术植入UHMWPE颗粒（2mg）或无颗粒的手术（假手术）之前接受了术前micro-CT扫描。在第7天通过腹膜内注射钙黄绿素在第9天进行动态标记，在第9天通过腹膜内注射alizarin进行动态标记。令人惊讶的是，我们发现AOX颗粒诱导的骨吸收明显增加（1.72倍）和破骨细胞数量（1.99倍）与AltrX（p <0.001）。然而，与AltrX相比，AOX还显着诱导了1.64倍的新骨形成（p <0.01）。此外，尽管两个颗粒的溶骨：成骨率都非常接近1.0，这表明偶联的重塑，但AOX的成骨性更高（斜率= 1.13 +/- 0.10对0.97 +/- 0.10）。代谢标记的未脱钙颅盖的组织形态计量学显示，AOX与AltrX的MAR呈一致趋势。总而言之，这些结果表明，由于抗氧化剂浸渍的UHMWPE颗粒增强了成骨特性，从而支持了耦合的骨重塑，因此其溶骨潜力降低。 （C）2015骨科研究学会。由Wiley Periodicals，Inc.发布

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