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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >In vivo bone response to porous calcium phosphate cement
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In vivo bone response to porous calcium phosphate cement

机译：体内骨骼对多孔磷酸钙水泥的反应

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摘要

We conducted an in vivo experiment to evaluate the resorption rate of a calcium phosphate cement (CPC) with macropores larger than 100 mu m, using the CPC called Biocement D (Merck Biomaterial, Darmstadt, Germany), which after setting only shows pores smaller than 1 mu m. The gas bubble method used during the setting process created macroporosity. Preset nonporous and porous cement implants were inserted into the trabecular bone of the tibial metaphysis of goats. The size of the preset implants was 6 mm and the diameter of the drill hole was 6.3 mm, leaving a gap of 0.3 mm between implant surface and drill wall. After 2 and 10 weeks, the animals were euthanized and cement implants with surrounding bone were retrieved for histologic evaluation. Light microscopy at 2 weeks revealed that the nonporous implants were surrounded by connective tissue. On the cement surface, we observed a monolayer of multinucleated cells. Ten weeks after implantation, the nonporous implants were still surrounded by connective tissue. However, a thin layer of bone now covered the implant surface. No sign of cement resorption was observed. In contrast, the porous cement evoked a completely different bone response. At 2 weeks, bone formation had already occurred inside the implant porosity. Bone formation even appeared to occur as a result of osteoinduction. Also, at their outer surface, the porous implants were completely surrounded by bone. At 2 weeks, about 31 percent of the initial cement was resorbed. After 10 weeks, 81 percent of the initial phosphate cement was resorbed and new bone was deposited. On the basis of these observations, we conclude that the creation of macropores can significantly improve the resorption rate of CPC. This increased degradation is associated with almost complete bone replacement.
机译：我们使用称为Biocement D（德国达姆施塔特的默克生物材料公司）的CPC进行了体内实验，以评估大孔大于100微米的磷酸钙水泥（CPC）的吸收速率，该产品在凝固后仅显示出小于1微米凝固过程中使用的气泡法会产生大孔。将预设的无孔和多孔水泥植入物插入山羊胫骨干physi端的小梁骨中。预设植入物的尺寸为6 mm，钻孔直径为6.3 mm，在植入物表面和钻壁之间留有0.3 mm的间隙。 2周和10周后，对动物实施安乐死并取回具有周围骨骼的水泥植入物以进行组织学评估。在第2周的光学显微镜检查显示无孔植入物被结缔组织包围。在水泥表面上，我们观察到了单层的多核细胞。植入后十周，无孔植入物仍被结缔组织包围。但是，现在薄薄的一层骨头覆盖了植入物表面。没有观察到水泥吸收的迹象。相反，多孔水泥引起了完全不同的骨骼反应。在第2周时，植入物孔隙内已经发生了骨形成。骨形成甚至由于骨诱导而出现。同样，多孔植入物在其外表面完全被骨头包围。在第2周，约31％的初始胶结物被重新吸收。 10周后，81％的初始磷酸盐胶结物被吸收，并沉积了新骨。基于这些观察，我们得出结论，大孔的产生可以显着提高CPC的吸收率。这种增加的降解与几乎完全的骨置换有关。

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