...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of artificial organs: The official journal of the Japanese Society for Artificial Organs >Acceleration of bone formation with BMP2 in frame-reinforced carbonate apatite-collagen sponge scaffolds.
【24h】

Acceleration of bone formation with BMP2 in frame-reinforced carbonate apatite-collagen sponge scaffolds.

机译：框架增强的碳酸盐磷灰石-胶原海绵支架中BMP2促进骨形成。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The development is expected of scaffold biomaterials that feature a shape-maintaining property in addition to high porosity and large pores that cells can easily invade. To develop a new biodegradable scaffold biomaterial reinforced with a frame, synthesized carbonate apatite (CO3Ap) was mixed with neutralized collagen gel, and the CO3Ap-collagen mixtures were lyophilized into sponges in a porous hydroxyapatite (HAp) frame ring. X-ray diffraction and Fourier transform infrared spectroscopy (FT-IR) analyses together with chemical analysis indicated that the synthesized CO3Ap had a crystalline nature and a chemical composition similar to that of bone. Scanning electron microscope (SEM) observation showed that the CO3Ap-collagen sponge had a sui pore size for cell invasion. In proliferation and differentiation experiments with osteoblasts, alkaline phosphatase and osteopontin activity were clearly detected. When these sponge-frame complexes with bone morphogenic protein (rh-BMP2) were implanted beneath the periosteum cranii of rats, significant new bone was created at the surface of the periosteum cranii after 4 weeks of implantation. These reinforced CO3Ap-collagen sponges with rh-BMP2 are expected to be used as hard tissue scaffold biomaterials for the therapeutic purpose of the rapid cure of bone defects.
机译：除了具有高孔隙率和细胞易于侵入的大孔之外，还具有保形特性的支架生物材料有望得到发展。为了开发一种新的具有框架增强的可生物降解的支架生物材料，将合成的碳酸盐磷灰石（CO3Ap）与中和的胶原蛋白凝胶混合，然后将CO3Ap-胶原蛋白混合物冻干成多孔的羟基磷灰石（HAp）框架环中的海绵。 X射线衍射和傅里叶变换红外光谱（FT-IR）分析以及化学分析表明，合成的CO3Ap具有类似于骨骼的晶体性质和化学组成。扫描电子显微镜（SEM）观察表明，CO3Ap-胶原海绵具有适合细胞入侵的独特孔径。在成骨细胞的增殖和分化实验中，清楚地检测到了碱性磷酸酶和骨桥蛋白的活性。当将这些具有骨形态发生蛋白（rh-BMP2）的海绵骨架复合物植入大鼠颅骨下方时，植入后4周，在颅骨表面会形成大量新的骨骼。这些具有rh-BMP2的增强型CO3Ap-胶原海绵有望用作硬组织支架生物材料，用于快速治愈骨缺损的治疗目的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号