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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >On the role of CO_2 laser treatment in the human serum albumin and human plasma fibronectin adsorption on zirconia (MGO-PSZ) bioceramic surface
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On the role of CO_2 laser treatment in the human serum albumin and human plasma fibronectin adsorption on zirconia (MGO-PSZ) bioceramic surface

机译：关于CO_2激光处理在氧化锆（MGO-PSZ）生物陶瓷表面吸附人血清白蛋白和血浆纤连蛋白中的作用

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The nature of the surface strongly influences the composition and recognizability of the adsorbed protein layer, which in turn affects the subsequent cellular interactions. Thus, to understand the biological response to a material, especially in vitro, one must fully understand the nature of the adsorbed protein film that forms on the material. This study investigates the fundamental interactions between the human serum albumin (no-cell adhesive) and human plasma fibronectin and bioinert ceramic following CO_2 laser treatment. The analysis of the albumin and fibronectin adsorption was conducted on the untreated and CO_2 laser-modified magnesia partially stabilized zirconia (MgO-PSZ) bioceramic using an ellipsometry. It was found that the adsorptions of albumin and fibronectin were influenced by the surface properties. The albumin adsorption was affected by the surface roughness and wettability characteristics of the MgO-PSZ and decreased with these properties, while the fibronectin adsorption was increased with wettability characteristics and predominantly governed by this property. Moreover, the considerable change in the polar component of surface energy, gamma_(sv)~p, and its effect on protein adsorption implied that the albumin and fibronectin adsorption on the MgO-PSZ surfaces was probably due to the polar and chemical interactions. The value of this work is to provide a novel technique and useful information for manipulating protein adsorption and thereof cellular interactions.
机译：表面的性质强烈影响吸附蛋白层的组成和可识别性，进而影响随后的细胞相互作用。因此，要了解对材料的生物学反应，尤其是在体外，必须充分了解在材料上形成的吸附蛋白膜的性质。这项研究调查了CO_2激光治疗后人血清白蛋白（无细胞粘合剂）与人血浆纤连蛋白和生物惰性陶瓷之间的基本相互作用。使用椭圆光度法对未经处理的和CO_2激光改性的氧化镁部分稳定的氧化锆（MgO-PSZ）生物陶瓷进行了白蛋白和纤连蛋白的吸附分析。发现白蛋白和纤连蛋白的吸附受表面性质的影响。白蛋白吸附受MgO-PSZ的表面粗糙度和润湿性特性影响，并随这些特性而降低，而纤连蛋白吸附则随着润湿性特性而增加，并主要受该特性支配。此外，表面能的极性分量γ_（sv）〜p的显着变化及其对蛋白质吸附的影响表明，MgO-PSZ表面的白蛋白和纤连蛋白吸附可能是由于极性和化学相互作用。这项工作的价值是为操纵蛋白质吸附及其细胞相互作用提供一种新颖的技术和有用的信息。

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