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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Surface topography can interfere with epithelial tissue migration.
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Surface topography can interfere with epithelial tissue migration.

机译：表面形貌可干扰上皮组织迁移。

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摘要

Corneal epithelial tissue migration over the surface of a synthetic polymer can be inhibited by pores in the substrate. The effects of this substrate topography upon epithelial tissue migration were studied in vitro. Membranes of different porosities and structures were used to provide two series of surfaces having a graded increase in discontinuities: cellulose nitrate/acetate membranes with a tortuous network of pores, and track-etched polycarbonate membranes with columnar pores. Corneal epithelial tissue outgrowth was inhibited by increased pore size, and for both series of membranes, outgrowth was completely halted on membranes with mean diameter of the pores 0.9 microm at the pore densities measured. On the track-etched membranes with pores of <0.9 microm diameter, tissue outgrowth could be partially "rescued" by coating with fibronectin or collagen, but above this size, the inhibition predominated. The effect of porosity of the track-etched membranes upon the migration of dissociated epithelial cells was also examined. Although migration of these cells was reduced on membranes having pore sizes larger than 0.9 microm, it was not completely inhibited even on membranes of 2.3-microm pore diameter. Therefore, tissue movement of adult stratified epithelium may be inhibited by specific surface topographies, and in this assay system, epithelial tissue outgrowth was more affected than was the migration of dissociated epithelial cells.
机译：角膜上皮组织在合成聚合物表面上的迁移可被基质中的孔抑制。体外研究了这种基底形貌对上皮组织迁移的影响。使用具有不同孔隙率和结构的膜来提供具有不连续性梯度增加的两个系列的表面：具有曲折孔网络的硝酸纤维素/乙酸纤维素膜和具有柱状孔的经轨迹蚀刻的聚碳酸酯膜。孔径增加抑制了角膜上皮组织的生长，并且对于这两个系列的膜，在测量的孔密度下，平均孔径为0.9微米的膜上的生长完全停止。在直径小于0.9微米的微孔蚀刻膜上，通过用纤连蛋白或胶原蛋白包被可以部分“挽救”组织的生长，但在该尺寸以上，抑制作用占主导。还检查了轨迹蚀刻膜的孔隙率对解离的上皮细胞迁移的影响。尽管在孔径大于0.9微米的膜上这些细胞的迁移减少了，但是即使在孔径为2.3微米的膜上也没有被完全抑制。因此，成年分层上皮的组织运动可能被特定的表面形貌所抑制，并且在该测定系统中，上皮组织的生长比解离的上皮细胞的迁移受到的影响更大。

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