Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives.

Jiang X; Zhou L; Wei D; Meng H; Liu Y; Lai L

首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives.

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Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives.

机译：二苯醚及其衍生物激活和抑制白三烯A4水解酶氨肽酶活性。

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The synthesis and biological evaluation of a series of diphenyl ether derivatives were described. The compounds can either activate or inhibit the aminopeptidase activity of leukotriene A(4) hydrolase, while at the same time do not influence the hydrolase activity. Further enzyme kinetics and molecular modeling investigation on these novel chemical activators revealed their possible activation mechanism. These compounds can be used as probes to regulate the aminopeptidase activity of leukotriene A(4) hydrolase.

机译：描述了一系列二苯醚衍生物的合成和生物学评价。该化合物可以激活或抑制白三烯A（4）水解酶的氨肽酶活性，而同时不影响水解酶的活性。对这些新型化学活化剂的进一步酶动力学和分子模型研究揭示了它们可能的活化机理。这些化合物可以用作探针，以调节白三烯A（4）水解酶的氨肽酶活性。

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来源
《Bioorganic and Medicinal Chemistry Letters》 |2008年第24期|共4页
作者
Jiang X; Zhou L; Wei D; Meng H; Liu Y; Lai L;
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正文语种 eng
中图分类药学;生物化学;
关键词
Aminopeptidases; derivatives; phenyl ether; Hydrolases; leukotriene A4 hydrolase; 氨肽酶类; 水解酶类;

机译：Aminopeptidases;derivatives;phenyl ether;Hydrolases;leukotriene A4 hydrolase;氨肽酶类;水解酶类;

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1. Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives. [J] . Jiang X, Zhou L, Wei D, Bioorganic and Medicinal Chemistry Letters . 2008,第24期

机译：二苯醚及其衍生物激活和抑制白三烯A4水解酶氨肽酶活性。
2. Leukotriene A4 hydrolase, a bifunctional enzyme Distinction of leukotriene A4 hydrolase and aminopeptidase activities by site‐directed mutagenesis at Glu‐297 [J] . Abe Keiko, Bito Haruhiko, Izumi Takashi, FEBS Letters . 1992,第3期

机译：白三烯A4水解酶，一种双功能酶，通过在Glu-297处的定点诱变来区分白三烯A4水解酶和氨基肽酶活性
3. Effect of Modifier Structure on the Activation of Leukotriene A(4) Hydrolase Aminopeptidase Activity [J] . Lee Kyung Hyeon, Petruncio Greg, Shim Amanda, Journal of Medicinal Chemistry . 2019,第23期

机译：改性剂结构对白三烯A（4）水解氨基肽酶活性的影响
4. Molecule Activity Analysis in Ground State of para-Halogenated Diphenyl Ethers Based on DFT Calculation [C] . Long Jiang, Yue Guo, Qing Li International Conference on Artificial Intelligence and Engineering Applications . 2017

机译：基于DFT计算的对卤代二苯基醚的地面状态分子活性分析
5. Characterization Of Novel Epoxide Hydrolase Activities On Epoxy Fatty Acids In Mosquitoes And Examination of How Epoxide Hydrolase Inhibition Affects Mosquito Physiology [D] . Xu, Jiawen 2015

机译：蚊子中环氧脂肪酸新的环氧水解酶活性的表征以及对环氧水解酶抑制作用如何影响蚊子生理的研究
6. Withdrawal: Identification of human aminopeptidase O a novel metalloprotease with structural similarity to aminopeptidase B and leukotriene A4 hydrolase. [O] . Araceli Díaz-Perales, Víctor Quesada, Luis M. Sánchez, 2019

机译：退出：鉴定人氨基肽酶O这是一种与氨基肽酶B和白三烯A4水解酶结构相似的新型金属蛋白酶。
7. Leukotriene A4 hydrolase, a bifunctional enzyme Distinction of leukotriene A4 hydrolase and aminopeptidase activities by site-directed mutagenesis at Glu-297 [O] . Minami Michiko, Bito Haruhiko, Ohishi Nobuya, 1992

机译：白三烯A4水解酶，一种双功能酶，通过在Glu-297处的定点诱变来区分白三烯A4水解酶和氨基肽酶活性

Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives.

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