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首页> 外文期刊>Journal of biomedicine & biotechnology >A Novel Model of Atherosclerosis in Rabbits Using Injury to Arterial Walls Induced by Ferric Chloride as Evaluated by Optical Coherence Tomography as well as Intravascular Ultrasound and Histology
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A Novel Model of Atherosclerosis in Rabbits Using Injury to Arterial Walls Induced by Ferric Chloride as Evaluated by Optical Coherence Tomography as well as Intravascular Ultrasound and Histology

机译：光学相干断层扫描以及血管内超声和组织学评估的一种新型兔动脉粥样硬化模型，利用氯化铁对氯化钙所致动脉壁损伤

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This study aim was to develop a new model of atherosclerosis by FeCl3-induced injury to right common carotid arteries (CCAs) of rabbits. Right CCAs were induced in male New Zealand White rabbits (n = 15) by combination of a cholesterol-rich diet and FeCl3-induced injury to arterial walls. The right and left CCAs were evaluated by histology and in vivo intravascular ultrasound (IVUS) and optical coherence tomography (OCT) examinations of 24 hours (n = 3), 8 weeks (n = 6), and 12 weeks (n = 6) after injury. Each right CCA of the rabbits showed extensive white-yellow plaques. At eight and 12 weeks after injury, IVUS, OCT, and histological findings demonstrated that the right CCAs had evident eccentric plaques. Six plaques (50%) with evident positive remodeling were observed. Marked progression was clearly observed in the same plaque at 12 weeks after injury when it underwent repeat OCT and IVUS. We demonstrated, for the first time, a novel model of atherosclerosis induced by FeCl3. The model is simple, fast, inexpensive, and reproducible and has a high success rate. The eccentric plaques and remodeling of plaques were common in this model. We successfully carried out IVUS and OCT examinations twice in the same lesion within a relatively long period of time.
机译：这项研究的目的是开发一种新的模型，该模型由FeCl3诱导的兔右颈总动脉（CCA）损伤形成。雄性新西兰白兔（n = 15）通过富含胆固醇的饮食和FeCl3诱导的对动脉壁的损伤而诱导了正确的CCA。通过组织学和体内血管内超声（IVUS）以及光学相干断层扫描（OCT）检查24小时（n = 3），8周（n = 6）和12周（n = 6）来评估左右CCA。受伤后。兔子的每一个右CCA都显示出广泛的白黄色斑块。受伤后八周和十二周，IVUS，OCT和组织学检查结果表明，正确的CCA有明显的偏心斑块。观察到六个斑块（50％）具有明显的正重塑。受伤后12周，当重复进行OCT和IVUS时，在同一斑块中明显观察到明显的进展。我们首次展示了由FeCl3诱导的动脉粥样硬化的新型模型。该模型简单，快速，廉价且可重现，成功率高。偏心斑块和斑块重塑在该模型中很常见。我们在相对长的时间内成功地在同一病变中两次进行了IVUS和OCT检查。

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