...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research >Effect of pregnancy on bone mineral density and biochemical markers of bone turnover in a patient with juvenile idiopathic osteoporosis.
【24h】

Effect of pregnancy on bone mineral density and biochemical markers of bone turnover in a patient with juvenile idiopathic osteoporosis.

机译：妊娠对青少年特发性骨质疏松症患者骨矿物质密度和骨转换生化指标的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Juvenile idiopathic osteoporosis (JIO) is rare, presenting with vertebral fractures in the immediate prepubertal years; however, recovery is normally observed. We report the case of a 19-year-old pregnant woman previously diagnosed with JIO. She experienced three vertebral fractures in the third trimester of pregnancy. She delivered by caesarean section at 38 weeks gestation. Spinal bone mineral density decreased by 25%, hip bone mineral density by 10%, and forearm bone mineral density by 3% during pregnancy. Bone resorption markers, free pyridinoline and deoxypyridinoline (fPYD and fDPD), were elevated at baseline and markedly increased during pregnancy (fPYD/fDPD at 0, 10, 15, 20, and 28 weeks and immediately postpartum: 36.2/11.5, 52.9/15.8, 54.3/13.3, 51.1/13.3, 90/21.8, and 95.6/22.7 nmol/mmol creatinine, respectively) The bone formation marker, bone-specific alkaline phosphatase (BSAP), was within the reference range at baseline and increased in the third trimester. (BSAP at 0, 10, 15, 20, and 28weeks and immediately postpartum: 20.5, 18.3, 17.7, 19.8, 26.9, and 30.0 U/liter, respectively). Parathyroid hormone (PTH) was measured by two methods to assess the possible effect of PTH fragments. PTH(1-84) (Roche) showed little change during the pregnancy, whereas the Nichols assay [(1-84) and(7-84) PTH fragment], revealed increases paralleling the changes in bone resorption. This young woman's bone turnover showed an exaggerated response to pregnancy, with bone resorption predominating over formation. PTH fragments may have partially mediated this effect.
机译：幼年特发性骨质疏松症（JIO）很少见，在青春期前即有椎体骨折。但是，通常可以观察到恢复。我们报告了先前诊断为JIO的19岁孕妇的病例。她在妊娠晚期三个椎骨骨折。她在妊娠38周时通过剖腹产分娩。在怀孕期间，脊椎骨矿物质密度降低了25％，髋骨矿物质密度降低了10％，前臂骨矿物质密度降低了3％。基线时基线吸收升高，游离吡啶和去氧吡啶啉（fPYD和fDPDD）的骨吸收标志物显着增加（妊娠0、10、15、20和28周时以及产后立即f​​PYD / fDPD：36.2 / 11.5、52.9 / 15.8 ，分别为54.3 / 13.3、51.1 / 13.3、90 / 21.8和95.6 / 22.7 nmol / mmol肌酐）骨形成标记物，骨特异性碱性磷酸酶（BSAP）在基线时处于参考范围内，在第三次时增加三个月。 （BSAP在0、10、15、20和28周以及产后立即分别为：20.5、18.3、17.7、19.8、26.9和30.0 U /升）。通过两种方法测量甲状旁腺激素（PTH），以评估PTH片段的可能作用。 PTH（1-84）（罗氏（Roche））在怀孕期间几乎没有变化，而Nichols分析[（1-84）和（7-84）PTH片段]显示出与骨吸收变化平行的增加。这位年轻女子的骨转换显示出对妊娠的过度反应，其中骨吸收占主导地位。 PTH片段可能部分介导了这种作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号