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首页> 外文期刊>Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research >Wnt signaling regulates pulp volume and dentin thickness
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Wnt signaling regulates pulp volume and dentin thickness

机译：Wnt信号调节牙髓体积和牙本质厚度

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Odontoblasts, cementoblasts, ameloblasts, and osteoblasts all form mineralized tissues in the craniofacial complex, and all these cell types exhibit active Wnt signaling during postnatal life. We set out to understand the functions of this Wnt signaling, by evaluating the phenotypes of mice in which the essential Wnt chaperone protein, Wntless was eliminated. The deletion of Wls was restricted to cells expressing Osteocalcin (OCN), which in addition to osteoblasts includes odontoblasts, cementoblasts, and ameloblasts. Dentin, cementum, enamel, and bone all formed in OCN-Cre;Wlsfl/fl mice but their homeostasis was dramatically affected. The most notable feature was a significant increase in dentin volume and density. We attribute this gain in dentin volume to a Wnt-mediated misregulation of Runx2. Normally, Wnt signaling stimulates Runx2, which in turn inhibits dentin sialoprotein (DSP); this inhibition must be relieved for odontoblasts to differentiate. In OCN-Cre;Wlsfl/fl mice, Wnt pathway activation is reduced and Runx2 levels decline. The Runx2-mediated repression of DSP is relieved and odontoblast differentiation is accordingly enhanced. This study demonstrates the importance of Wnt signaling in the homeostasis of mineralized tissues of the craniofacial complex.
机译：成牙本质细胞，成骨细胞，成釉细胞和成骨细胞均在颅面复合物中形成矿化组织，并且所有这些细胞类型在产后生活中均表现出活跃的Wnt信号传导。我们着手通过评估其中必需的Wnt伴侣蛋白Wntless被消除的小鼠的表型来了解Wnt信号转导的功能。 W1s的缺失仅限于表达成骨钙素（OCN）的细胞，除成骨细胞外，成骨细胞还包括成牙本质细胞，成骨细胞和成釉细胞。牙本质，牙骨质，牙釉质和骨骼均在OCN-Cre; Wlsfl / fl小鼠中形成，但其体内稳态受到显着影响。最显着的特征是牙本质体积和密度显着增加。我们将这种牙本质体积增加归因于Wnt介导的Runx2调控失调。通常，Wnt信号传导会刺激Runx2，而Runx2又会抑制牙本质唾液蛋白（DSP）。为了使成牙本质细胞分化，必须解除这种抑制作用。在OCN-Cre; Wlsfl / fl小鼠中，Wnt途径的激活减少，Runx2水平下降。减轻了Runx2介导的DSP抑制，从而增强了成牙本质细胞的分化。这项研究证明了Wnt信号在颅面复合物矿化组织的体内平衡中的重要性。

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