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首页> 外文期刊>Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research >Longitudinal changes of bone density and bone resorption in hyperthyroid girls during treatment.
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Longitudinal changes of bone density and bone resorption in hyperthyroid girls during treatment.

机译：治疗期间甲状腺功能亢进女孩的骨密度和骨吸收的纵向变化。

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摘要

Low bone mineral density (BMD) and increased bone turnover are common features of untreated hyperthyroidism in adult patients. The effect of treatment on BMD is still controversial. BMD and bone metabolism in hyperthyroid children have not been thoroughly investigated. In the present study, we measured spinal and whole body BMD by dual-energy X-ray absorptiometry in a group of 13 girls (aged 5.0-14.9 years) at diagnosis of hyperthyroidism. The bone resorption rate was assessed by urine measurement of N-terminal telopeptide of type I collagen (NTX). Hyperthyroid patients have been studied longitudinally during treatment. BMD values and NTX urine concentrations have been also determined in 155 healthy Caucasian girls (aged 2.4-24.2 years). Spinal and whole body bone density measurements were significantly lower compared with healthy controls in untreated hyperthyroid girls, after correction for differences in age and anthropometric measurements (p
机译：低骨矿物质密度（BMD）和增加骨转换是成年患者未经治疗的甲亢的常见特征。治疗对骨密度的影响仍存在争议。甲状腺功能亢进儿童的骨密度和骨代谢尚未得到彻底研究。在本研究中，我们通过双能X射线吸收测定法对诊断为甲亢的13名女孩（年龄5.0-14.9岁）进行了脊柱和全身BMD测量。通过尿液测量I型胶原（NTX）的N端端肽评估骨吸收率。甲状腺功能亢进患者已在治疗过程中进行了纵向研究。还确定了155名健康的白人女孩（2.4-24.2岁）的BMD值和NTX尿液浓度。校正年龄和人体测量学差异后，未经治疗的甲状腺功能亢进女孩的脊柱和全身骨密度测量值均显着低于健康对照组（p

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