...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research >Adaptation of the proximal femur to skeletal reloading after long-duration spaceflight.
【24h】

Adaptation of the proximal femur to skeletal reloading after long-duration spaceflight.

机译：长时间太空飞行后，股骨近端适应骨骼再加载。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We studied the effect of re-exposure to Earth's gravity on the proximal femoral BMD and structure of astronauts 1 year after missions lasting 4-6 months. We observed that the readaptation of the proximal femur to Earth's gravity entailed an increase in bone size and an incomplete recovery of volumetric BMD. INTRODUCTION: Bone loss is a well-known result of skeletal unloading in long-duration spaceflight, with the most severe losses occurring in the proximal femur. However, there is little information about the recovery of bone loss after mission completion and no information about effect of reloading on the structure of load-bearing bone. To address these questions, we carried out a study of the effect of re-exposure to Earth's gravity on the BMD and structure of the proximal femur 1 year after missions lasting 4-6 months. MATERIALS AND METHODS: In 16 crew members of the International Space Station (ISS) making flights of 4.5-6 months, we used QCT imaging to measure the total, trabecular, and cortical volumetric BMD (vBMD) of the proximal femur. In addition to vBMD, we also quantified BMC, bone volume, femoral neck cross-sectional area (CSA), and femoral neck indices of compressive and bending strength at three time-points: preflight, postflight, and 1 year after mission. RESULTS: Proximal femoral bone mass was substantially recovered in the year after spaceflight, but measures of vBMD and estimated bone strength showed only partial recovery. The recovery of BMC, in the absence of a comparable increase in vBMD, was explained by increases in bone volume and CSA during the year after spaceflight. CONCLUSIONS: Adaptation of the proximal femur to reloading entailed an increase in bone size and an incomplete recovery of vBMD. The data indicate that recovery of skeletal density after long-duration space missions may exceed 1 year and supports the evidence in the aging literature for periosteal apposition as a compensatory response for bone loss. The extent to which this compensatory effect protects against fracture remains to be seen.
机译：我们研究了在持续4-6个月的任务后1年，再暴露于地球重力对股骨近端BMD和宇航员结构的影响。我们观察到股骨近端对地球重力的重新适应导致骨大小增加和体积骨密度的恢复不完全。简介：骨丢失是长时间航天中骨骼卸载的众所周知的结果，最严重的丢失发生在股骨近端。但是，关于任务完成后骨丢失恢复的信息很少，也没有关于再加载对承重骨结构影响的信息。为了解决这些问题，我们对任务进行了4-6个月后的1年，进行了重新暴露于地球重力对股骨近端BMD和结构的影响的研究。材料与方法：在国际空间站（ISS）的16名机组成员中进行了4.5-6个月的飞行，我们使用QCT成像来测量股骨近端的总，小梁和皮质体积BMD（vBMD）。除了vBMD，我们还对飞行前，飞行后和术后1年三个时间点的BMC，骨量，股骨颈横截面积（CSA）以及股骨颈抗压强度和弯曲强度指数进行了量化。结果：航天飞行后的一年，股骨近端骨量基本恢复，但vBMD和骨强度估算值仅显示部分恢复。在vBMD没有可比增加的情况下，BMC的恢复可以通过航天后一年中的骨量和CSA的增加来解释。结论：股骨近端适应于重载导致骨大小增加和vBMD恢复不完全。数据表明，长期太空飞行后骨骼密度的恢复可能会超过1年，并支持老化文献中骨膜并置作为骨丢失的补偿性反应的证据。这种补偿作用防止骨折的程度尚待观察。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号