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首页> 外文期刊>Journal of Biomolecular Structure and Dynamics >Cell communication using intrinsically disordered proteins: what can syndecans say?
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Cell communication using intrinsically disordered proteins: what can syndecans say?

机译：使用内在无序的蛋白质进行细胞通讯：共济会会怎么说？

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Because intrinsically disordered proteins are incapable of forming unique tertiary structures in isolation, their interaction with partner structures enables them to play important roles in many different biological functions. Therefore, such proteins are usually multifunctional, and their ability to perform their major function, as well as accessory functions, depends on the characteristics of a given interaction. The present paper demonstrates, using predictions from two programs, that the transmembrane proteoglycans syndecans are natively disordered because of their diverse functions and large number of interaction partners. Syndecans perform multiple functions during development, damage repair, tumor growth, angiogenesis, and neurogenesis. By mediating the binding of a large number of extracellular ligands to their receptors, these proteoglycans trigger a cascade of reactions that subsequently regulate various cell processes: cytoskeleton formation, proliferation, differentiation, adhesion, and migration. The occurrences of 20 amino acids in syndecans 1-4 from 25 animals were compared with those in 17 animal proteomes. Gly + Ala, Thr, Glu, and Pro were observed to predominate in the syndecans, contributing to the lack of an ordered structure. In contrast, there were many fewer amino acids in syndecans that promote an ordered structure, such as Cys, Trp, Asn, and His. In addition, a region rich in Asp has been identified between two heparan sulfate-binding sites in the ectodomains, and a region rich in Lys has been identified in the conserved C1 site of the cytoplasmic domain. These particular regions play an essential role in the various functions of syndecans due to their lack of structure.
机译：由于内在无序的蛋白质无法孤立地形成独特的三级结构，因此它们与伴侣结构的相互作用使它们在许多不同的生物学功能中发挥重要作用。因此，这类蛋白质通常是多功能的，它们执行其主要功能以及辅助功能的能力取决于给定相互作用的特征。本文使用两个程序的预测证明，跨膜蛋白聚糖合成多糖由于其功能多样和相互作用伙伴众多而天然失调。 Syndecans在发育，损伤修复，肿瘤生长，血管生成和神经发生过程中执行多种功能。通过介导大量细胞外配体与其受体的结合，这些蛋白聚糖引发了一系列反应，随后调节了各种细胞过程：细胞骨架的形成，增殖，分化，粘附和迁移。将来自25只动物的Syndecans 1-4中20个氨基酸的出现与17种动物蛋白质组中的氨基酸进行了比较。观察到Gly + Ala，Thr，Glu和Pro在Syndecans中占主导地位，导致缺乏有序结构。相比之下，能够促进有序结构的双癸聚糖中的氨基酸要少得多，例如Cys，Trp，Asn和His。另外，已经在胞外域的两个硫酸乙酰肝素结合位点之间鉴定出富含Asp的区域，并且在胞质域的保守C1位点鉴定出了富含Lys的区域。由于缺乏结构，这些特定区域在Syndecans的各种功能中起着至关重要的作用。

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