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首页> 外文期刊>Journal of Biomolecular Structure and Dynamics >Sequence-dependent flexibility in promoter sequences.
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Sequence-dependent flexibility in promoter sequences.

机译：启动子序列中依赖序列的灵活性。

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The non-neighbor interactions between base-pairs were taken into account to calculate the angular parameters (Omega, rho and tau) describing the orientation of successive base-pair planes and the translation parameters (D(y)) along the long axis of base-pair steps for 36 independent tetramers. A statistical mechanical model was proposed to predict the DNA flexibility that is mainly related to the thermal fluctuations at individual base-pair steps. The DNA flexibility can be described by the root-mean-square deviation of the end-to-end distance of DNA helical structure. The present model was then used to investigate the extreme flexible pattern in prokaryotic and eukaryotic promoter sequences. The results demonstrated several extreme flexible regions related to functionally important elements exist both in prokaryotic promoters and in eukaryotic promoters, DNA flexibility and AT content are highly correlated. The probabilities finding flexibility pattern in promoter sequences were also estimated statistically. The biological implications were discussed briefly.
机译：考虑了碱基对之间的非相邻相互作用，以计算描述连续碱基对平面的方向的角参数（Ω，rho和tau）和沿碱基长轴的平移参数（D（y）） 36个独立四聚体的双配对步骤。提出了统计力学模型来预测DNA柔性，该柔性主要与各个碱基对步骤的热波动有关。 DNA柔韧性可以通过DNA螺旋结构的端到端距离的均方根偏差来描述。然后，本模型用于研究原核和真核启动子序列中的极端柔性模式。结果表明，在原核启动子和真核启动子中都存在与功能重要元件相关的几个极端柔性区域，DNA柔性和AT含量高度相关。还统计地估计了在启动子序列中发现柔性模式的概率。简要讨论了生物学意义。

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