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首页> 外文期刊>Journal of Biomolecular Structure and Dynamics >Analysis of the information structure of protein sequences: a new method for analyzing the domain organization of proteins.
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Analysis of the information structure of protein sequences: a new method for analyzing the domain organization of proteins.

机译：蛋白质序列信息结构分析：一种分析蛋白质域结构的新方法。

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摘要

The amino acid sequences of gamma-crystallin, Haloalkane Dehalogenase, Phthalate Dioxygenase, Porphobilinogen Deaminase and Myosin Regulatory Domain c-chain were analyzed for their information content. Sites of increased degree of information coordination between residues (IDIC-sites) were identified, and their organization was studied by means of analyzing the information structure of the protein sequences. Relationships between the structural units forming the spatial and informational structure of proteins were demonstrated. Associations of information-coordinated structural elements (IDIC-associations) were mapped onto compact structural domains found in the spatial structures of globular proteins. The proposed method of analyzing the information structure of protein sequences may find applications in the biotechnology and structural chemistry of proteins.
机译：分析了γ-晶状蛋白，卤代烷脱卤酶，邻苯二甲酸二加氧酶，卟啉胆碱脱氨酶和肌球蛋白调节域c链的氨基酸序列的信息含量。鉴定出残基之间信息协调度提高的位点（IDIC位点），并通过分析蛋白质序列的信息结构来研究其组织。证明形成蛋白质的空间和信息结构的结构单元之间的关系。信息协调的结构元素的关联（IDIC关联）被映射到球形蛋白质的空间结构中发现的紧凑的结构域。所提出的分析蛋白质序列信息结构的方法可以在蛋白质的生物技术和结构化学中找到应用。

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