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Oxidative stress markers are elevated in exhaled breath condensate of workers exposed to nanoparticles during iron oxide pigment production

机译:氧化铁颜料生产过程中暴露于纳米颗粒的工人的呼出气冷凝物中氧化应激指标升高

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摘要

Markers of oxidative stress and inflammation were analysed in the exhaled breath condensate (EBC) and urine samples of 14 workers (mean age 43 +/- 7 years) exposed to iron oxide aerosol for an average of 10 +/- 4 years and 14 controls (mean age 39 +/- 4 years) by liquid chromatography-electrospray ionization-mass spectrometry/mass spectrometry (LC-ESI-MS/MS) after solid-phase extraction. Aerosol exposure in the workplace was measured by particle size spectrometers, a scanning mobility particle sizer (SMPS) and an aerodynamic particle sizer (APS), and by aerosol concentration monitors, P-TRAK and DustTRAK DRX.
机译:在14名工人(平均年龄为+/- 7岁),暴露于氧化铁气溶胶中平均10 +/- 4年的呼气冷凝物(EBC)和尿液样本中,分析了氧化应激和炎症的标志物,以及14名对照固相萃取后,用液相色谱-电喷雾电离质谱/质谱(LC-ESI-MS / MS)测定(平均年龄39±4岁)。通过粒度光谱仪,扫描迁移率粒度仪(SMPS)和空气动力学粒度仪(APS)以及气溶胶浓度监测仪P-TRAK和DustTRAK DRX来测量工作场所中的气溶胶暴露。

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