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Quantitative determination of metabolization dynamics by a real-time ~(13)CO_2 breath test

机译:实时〜(13)CO_2呼气试验定量测定代谢动力学

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摘要

We have developed a flow-through fast liver investigation packet (FLIP) to quantitatively measure the amount of exhaled ~(13)CO_2, as a result of liver metabolization processes. The FLIP system allows investigation of every single breath in real time. Line width variations due to interactions with other gas components disturb traditional measurements and limit their sensitivity to the ppm range. Detection of the complete breath volume and the spectrally fully resolved line shape allows sensitivity in the ppb range with a standard deviation of approximately 80 ppb, a prerequisite to quantitatively analyze liver metabolization processes.
机译:我们已经开发了一种流式快速肝脏检查包(FLIP),以定量测量由于肝脏代谢过程而呼出的〜(13)CO_2的量。 FLIP系统允许实时调查每一次呼吸。由于与其他气体成分相互作用而引起的线宽变化会干扰传统测量,并将其灵敏度限制在ppm范围内。检测完整的呼吸量和光谱上完全分辨的线形可以使灵敏度在ppb范围内,标准偏差约为80 ppb,这是定量分析肝脏代谢过程的前提。

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