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首页> 外文期刊>Journal of breath research >Inhaled today, not gone tomorrow: Pharmacokinetics and environmental exposure of volatiles in exhaled breath
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Inhaled today, not gone tomorrow: Pharmacokinetics and environmental exposure of volatiles in exhaled breath

机译：今天吸入，明天不消失：呼出气中的挥发物的药代动力学和环境暴露

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摘要

The chemical analysis of exhaled breath gas to assess state of health or identify disease biomarkers has gained growing interest in recent years, with advances in new technologies providing scientists and physicians with a powerful analytical arsenal with which to tackle pertinent issues. The application of these methods for pharmacokinetic studies, however, has received less attention despite its enormous potential in this field. For instance, breath gas analysis may be employed to characterize uptake and distribution within the body of exogenous volatile compounds, either from a pharmaceutical point of view, or in relation to environmental inhalation exposure. Both of these topics can benefit greatly from utilizing breath gas complementarily or as a surrogate to blood as an analytical medium, since breath sampling is non-invasive, inexhaustible, and is achievable with a frequency far exceeding that which is feasible for blood. However, because of the efficiency with which certain exogenous compounds are reflected in breath, this can also often be a significant source of confounding variables that require consideration in routine breath gas analyses. This paper provides an overview of the possibilities of breath gas analysis for pharmacokinetics and environmental exposure investigations and discusses the presence of exogenous compounds in standard breath analyses and their repercussions in terms of erroneous data interpretation.
机译：近年来，随着新技术的进步为科学家和医师提供了解决相关问题的强大分析工具，呼出气的化学分析以评估健康状况或确定疾病的生物标志物已引起越来越多的关注。然而，尽管这些方法在药代动力学研究中的应用在该领域具有巨大潜力，但受到的关注较少。例如，从药物学角度或与环境吸入接触有关，可采用呼吸气体分析来表征外源挥发性化合物在体内的吸收和分布。由于呼吸采样是非侵入性的，取之不尽，并且可以以远远超过血液可行的频率实现，因此这两个主题都可以通过互补地利用呼吸气体或作为血液的替代物而大大受益。但是，由于某些外源性化合物在呼吸中的反应效率很高，因此通常也可能是需要在常规呼吸气体分析中加以考虑的混杂变量的重要来源。本文概述了用于药代动力学和环境暴露研究的呼吸气体分析的可能性，并讨论了标准呼吸分析中外源性化合物的存在及其对数据解释错误的影响。

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