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首页> 外文期刊>Journal of Camel Practice and Research >Influence of camel milk on glycoprotein components in streptozotocin-diabetic rats.
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Influence of camel milk on glycoprotein components in streptozotocin-diabetic rats.

机译：骆驼奶对链脲佐菌素-糖尿病大鼠糖蛋白成分的影响。

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Camel milk is different from other ruminant milk; having low cholesterol; low sugar; high minerals especially zinc; high vitamin C; low protein and large concentrations of insulin. In Saudi Arabia, camel milk is traditionally used for many medical approaches. In the long-term effect of camel milk in type 2 diabetic rats on antihyperglycaemic, antioxidants, antihyperlipidaemic, and membrane bound ATPases was investigated, and its effect was shown in our previous study. The levels of glycoproteins were altered in experimental diabetes mellitus. Diabetes was induced in albino Wistar rats by a single intraperitoneal injection of streptozotocin (STZ) (40 mg/kg body weight). Diabetic rats exhibited significantly (P<0.05) increased levels of plasma glucose and decreased levels of plasma insulin. Also, significantly (P<0.05) increased levels of glycoproteins (hexose, hexosamine, fucose and sialic acid) were observed in serum, liver, and kidney of diabetic rats. Rats were treated with camel milk (250 ml/day) for a period of 45 days. Diabetic rats treated with camel milk showed significantly (P<0.05) decreased levels of glucose and glycoproteins and increased levels of insulin after 45 days. A similar effect was observed in diabetic rats treated with glibenclamide (600 micro g/kg body weight). Normal rats treated with camel milk (250 ml/day) did not show any significant (P<0.05) effect on glucose, insulin and glycoproteins. The results of our study showed that camel milk has the potential to reduce glucose and glycoproteins levels and increase insulin levels in STZ-induced experimental diabetes mellitus in rats.
机译：骆驼奶与其他反刍动物奶不同。低胆固醇低糖高矿物质，尤其是锌;高维生素C;低蛋白和高浓度胰岛素。在沙特阿拉伯，骆驼奶传统上用于许多医疗方法。在骆驼奶对2型糖尿病大鼠的长期抗降血糖，抗氧化剂，抗高血脂和膜结合ATP酶的长期作用中，对它的作用进行了研究。实验性糖尿病患者的糖蛋白水平发生了改变。通过单次腹腔注射链脲佐菌素（STZ）（40 mg / kg体重）在白化Wistar大鼠中诱发糖尿病。糖尿病大鼠表现出显着（P <0.05）的血浆葡萄糖水平升高和血浆胰岛素水平降低。同样，在糖尿病大鼠的血清，肝脏和肾脏中观察到糖蛋白（己糖，己胺，岩藻糖和唾液酸）水平显着（P <0.05）增加。用骆驼奶（250毫升/天）治疗大鼠45天。骆驼奶治疗的糖尿病大鼠在45天后显示出显着（P <0.05）的葡萄糖和糖蛋白水平降低和胰岛素水平升高。在用格列本脲（600微克/千克体重）治疗的糖尿病大鼠中观察到了类似的效果。用骆驼奶（250毫升/天）治疗的正常大鼠对葡萄糖，胰岛素和糖蛋白没有显示任何显着（P <0.05）影响。我们的研究结果表明，骆驼奶具有降低STZ诱导的实验性糖尿病大鼠葡萄糖和糖蛋白水平并增加胰岛素水平的潜力。

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