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首页> 外文期刊>Journal of cardiac failure >Cardiorenal rescue study in acute decompensated heart failure: Rationale and design of CARRESS-HF, for the heart failure clinical research network
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Cardiorenal rescue study in acute decompensated heart failure: Rationale and design of CARRESS-HF, for the heart failure clinical research network

机译：急性失代偿性心力衰竭的心脏肾脏抢救研究：CARRESS-HF的原理和设计，用于心力衰竭临床研究网络

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Background: Worsening renal function is common among patients hospitalized for acute decompensated heart failure (ADHF). When this occurs, subsequent management decisions often pit the desire for effective decongestion against concerns about further worsening renal function. There are no evidence-based treatments or guidelines to assist in these difficult management decisions. Ultrafiltration is a potentially attractive alternative to loop diuretics for the management of fluid overload in patients with ADHF and worsening renal function. Methods and Results: The National Heart, Lung, and Blood Institute Heart Failure Clinical Research Network designed a clinical trial to determine if ultrafiltration results in improved renal function and relief of congestion compared with stepped pharmacologic care when assessed 96 hours after randomization in patients with ADHF and cardiorenal syndrome. Enrollment began in June 2008. This paper describes the rationale and design of the Cardiorenal Rescue Study in Acute Decompensated Heart Failure (CARRESS-HF). Conclusions: Treating the signs and symptoms of congestion in ADHF is often complicated by worsening renal function. CARRESS-HF compares treatment strategies (ultrafiltration vs stepped pharmacologic care) for the management of worsening renal function in patients with ADHF. The results of the CARRESS-HF trial are expected to provide information and evidence as to the most appropriate approaches for treating this challenging patient population.
机译：背景：急性失代偿性心力衰竭（ADHF）住院的患者中，肾功能恶化是很常见的。当发生这种情况时，后续的管理决策常常使人们对有效充血的渴望与对肾功能进一步恶化的担忧相提并论。没有基于证据的治疗方法或指南可以帮助做出这些困难的管理决策。对于ADHF和肾功能恶化的患者，超滤是loop利尿剂的潜在诱人替代品，可用于管理体液超负荷。方法和结果：美国国家心肺血液研究所心力衰竭临床研究网络设计了一项临床试验，以确定在随机分配96小时后对ADHF患者进行评估时，与分级药物治疗相比，超滤是否可改善肾脏功能并减轻充血和心肾综合征。这项研究于2008年6月开始。本文介绍了急性失代偿性心力衰竭（CARRESS-HF）的心脏肾脏抢救研究的原理和设计。结论：治疗ADHF充血的体征和症状通常会伴有肾功能恶化。 CARRESS-HF比较了ADHF患者肾功能恶化的治疗策略（超滤与阶梯式药理治疗）。预计CARRESS-HF试验的结果将为治疗这种具有挑战性的患者群体提供最合适的方法的信息和证据。

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