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首页> 外文期刊>Journal of cardiac failure >Serum glutathione S-transferase P1 1 in prediction of cardiac function
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Serum glutathione S-transferase P1 1 in prediction of cardiac function

机译：血清谷胱甘肽S-转移酶P1 1预测心功能

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Background: Glutathione S-transferase P1 1 (GSTP1) belongs to the multigene isozyme family involved in cellular response to oxidative stress and apoptosis. Our initial retrospective proteomic analysis suggested that GSTP1 is associated with heart failure (HF). Although pro-B-type natriuretic peptide (proBNP) serves currently as a surrogate diagnostic and prognostic parameter in HF patients, its specificity remains uncertain. We hypothesized that GSTP1 might be a useful serum marker in the monitoring of HF patients. Methods and Results: Serum GSTP1 and proBNP were prospectively measured in 193 patients subdivided based on their ejection fraction (EF) either in equal-sized quintiles or predefined EF groups >52%, 43%-52%, 33%-42%, 23%-32% and ≤22%. At a cutoff of ≥231 ng/mL, GSTP1 identified HF patients with EF ≤22% with 81% sensitivity and 83% specificity, and at a cutoff of ≥655 pg/mL, proBNP identified the same patient group with 84% sensitivity and 22% specificity. GSTP1 at a ≥126 ng/mL cutoff identified EF ≤42% with 90% sensitivity and 95% specificity, or proBNP at a ≥396 pg/mL cutoff had 97% sensitivity and 20% specificity. In regression analyses, GSTP1, but not proBNP, discriminated between EF ≤42% and EF >42% in HF patients. Conclusions: These results suggest that GSTP1 is strongly associated with HF and could serve as a sensitive and specific marker to predict the ventricular function in HF patients.
机译：背景：谷胱甘肽S转移酶P1 1（GSTP1）属于多基因同工酶家族，参与细胞对氧化应激和凋亡的反应。我们最初的回顾性蛋白质组学分析表明，GSTP1与心力衰竭（HF）相关。尽管前B型利钠肽（proBNP）目前可作为HF患者的替代诊断和预后参数，但其特异性仍不确定。我们假设GSTP1可能是监测HF患者的有用血清标志物。方法和结果：前瞻性测量了193名根据其射血分数（EF）细分为相等大小的五分位数或预定EF组的患者的血清GSTP1和proBNP> 52％，43％-52％，33％-42％，23 ％-32％和≤22％。在临界值≥231ng / mL时，GSTP1鉴定出EF≤22％的HF患者，灵敏度为81％，特异性为83％，在临界值≥655pg / mL时，proBNP鉴定出同一患者组，灵敏度为84％，特异性为22％。截止值≥126 ng / mL的GSTP1鉴定为EF≤42％，灵敏度为90％，特异性为95％，或者截止值≥396pg / mL的proBNP，灵敏度为97％，特异性为20％。在回归分析中，在HF患者中，GSTP1而非proBNP区分出EF≤42％和EF> 42％。结论：这些结果表明，GSTP1与HF密切相关，可以作为预测HF患者心室功能的敏感和特异性标志物。

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