A mechanosensitive cation channel in endothelial cells.

Yao X; Kwan HY; Huang Y

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A mechanosensitive cation channel in endothelial cells.

机译：内皮细胞中的机械敏感阳离子通道。

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A mechanosensitive Ca2+-permeable channel is present in vascular endothelial cells. The activity of this channel increases in response to hemodynamic blood flow. Recently, it has been found that the activity of this channel may be regulated by cGMP through a protein kinase G-dependent pathway. Inhibition of the channel by cGMP abolishes the Ca2+ influx elicited by flow. Several inhibitors of the cation channel including Gd3+, Ni2+, and SK&F-96365 also inhibit the Ca2+ influx due to flow stimulation. These data suggest that a mechanosensitive cation channel is the primary pathway mediating the flow-induced Ca2+ entry in vascular endothelial cells.

机译：机械敏感的Ca2 +渗透通道存在于血管内皮细胞中。响应血液动力学血流，该通道的活性增加。最近，已经发现该通道的活性可以通过蛋白激酶G依赖性途径被cGMP调节。 cGMP对通道的抑制作用消除了由流动引起的Ca2 +内流。包括Gd3 +，Ni2 +和SK＆F-96365在内的几种阳离子通道抑制剂还可以抑制由于流动刺激而引起的Ca2 +流入。这些数据表明，机械敏感阳离子通道是介导血管内皮细胞中血流诱导的Ca2 +进入的主要途径。

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来源
《Journal of cardiac surgery.》 |2002年第4期|共2页
作者
Yao X; Kwan HY; Huang Y;
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正文语种 eng
中图分类外科学;
关键词
Calcium Channels; Endothelium; Vascular; Biological Factors; endothelium dependent hyperpolarization factor; 钙通道; 内皮; 血管;

机译：Calcium Channels;Endothelium;Vascular;Biological Factors;endothelium dependent hyperpolarization factor;钙通道;内皮;血管;

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1. A mechanosensitive cation channel in endothelial cells. [J] . Yao X, Kwan HY, Huang Y Journal of cardiac surgery. . 2002,第4期

机译：内皮细胞中的机械敏感阳离子通道。
2. Mechanosensitive Release of Adenosine 50-triphosphate Through Pannexin Channels and Mechanosensitive Upregulation of Pannexin Channels in Optic Nerve Head Astrocytes: A Mechanism for Purinergic Involvement in Chronic Strain [J] . Jonathan M. Beckel, Arthur J. Argall, Jason C. Lim, Glia . 2014,第9期

机译：通过Pannexin通道的机械敏感释放的三磷酸腺苷50和视觉神经头星形胶质细胞中Pannexin通道的机械敏感上调：嘌呤能参与慢性毒株的机制。
3. Mechanosensitive behavior of bacterial cyclic nucleotide gated (bCNG) ion channels: Insights into the mechanism of channel gating in the mechanosensitive channel of small conductance superfamily [J] . MalcolmH.R., ElmoreD.E., MaurerJ.A. Biochemical and Biophysical Research Communications . 2012,第3期

机译：细菌环状核苷酸门控（bCNG）离子通道的机械敏感性行为：洞察小电导超家族的机械敏感性通道中的通道门控机制
4. Arterial shear stress frequency regulates the mechanosensitive discrimination of endothelial responsiveness [C] . Blackman, B.R., Garcia-Cardena, . 2002

机译：动脉切应力频率调节对内皮反应性的机械敏感性判别
5. The functional incorporation of the mechanosensitive channel of large conductance within a tethered lipid bilayer and the future reconstitution of future designer channels. [D] . Wilson, Danyell S. 2009

机译：在束缚的脂质双层内大电导的机械敏感通道的功能性整合以及未来设计者通道的未来重构。
6. Ca(2+)-dependent non-selective cation and potassium channels activated by bradykinin in pig coronary artery endothelial cells. [O] . A Baron, M Frieden, F Chabaud, 1996

机译：Ca（2+）依赖性非选择性阳离子和钾通道被缓激肽激活在猪冠状动脉内皮细胞中。
7. Ca(2+)-dependent non-selective cation and potassium channels activated by bradykinin in pig coronary artery endothelial cells. [O] . Baron, A, Frieden, M, Chabaud, F, 1996

机译：Ca（2+）依赖性非选择性阳离子和钾通道被缓激肽激活在猪冠状动脉内皮细胞中。

A mechanosensitive cation channel in endothelial cells.

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