Role of kappa opioid receptor in cardioprotection of preconditioning: implications in cardiac surgery.

Wong TM; Wu S

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Role of kappa opioid receptor in cardioprotection of preconditioning: implications in cardiac surgery.

机译：κ阿片受体在心脏预处理中的作用：在心脏手术中的意义。

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Kappa-opioid receptor mediates both immediate and delayed cardioprotection of ischemic/metabolic inhibition preconditioning. Both PKC and mitochondria ATP-sensitive K+ channel, mediate the protective action of kappa-opioid receptor stimulation. In delayed cardioprotection, PKC-epsilon may produce its effect via mitochondria ATP-sensitive K+ channel, and a stress inducible heat stress protein 70 may also be involved. Metabolic inhibition causes cell death which is accompanied by Ca2+ overload and mobilization of Ca2+ from sarcoplasmic reticulum to cytoplasm. The altered Ca2+ homeostasis is restored partially by kappa-opioid receptor or metabolic inhibition preconditioning. The finding indicates that opioids such as morphine may be used in the treatment of ischemic heart diseases and in open heart surgery.

机译：κ阿片受体介导缺血/代谢抑制预处理的即时和延迟心脏保护作用。 PKC和线粒体ATP敏感的K +通道均介导κ阿片受体刺激的保护作用。在延迟的心脏保护中，PKC-ε可能通过线粒体ATP敏感的K +通道产生作用，并且还可能涉及应激诱导的热应激蛋白70。代谢抑制导致细胞死亡，并伴有Ca2 +超载和Ca2 +从肌浆网转移到细胞质。 Ca2 +阿片受体或代谢抑制预处理可部分恢复改变的Ca2 +稳态。该发现表明，吗啡等阿片类药物可用于缺血性心脏病的治疗和开放性心脏手术。

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《Journal of cardiac surgery.》 |2002年第5期|共3页
作者
Wong TM; Wu S;
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正文语种 eng
中图分类外科学;
关键词
Ischemic Preconditioning; Myocardial; Myocardial Reperfusion Injury; Receptors; Opioid; kappa; 缺血预处理; 心肌; 心肌再灌注损伤; 受体; 阿片样; κ;

机译：Ischemic Preconditioning;Myocardial;Myocardial Reperfusion Injury;Receptors;Opioid;kappa;缺血预处理;心肌;心肌再灌注损伤;受体;阿片样;κ;

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1. Role of kappa opioid receptor in cardioprotection of preconditioning: implications in cardiac surgery. [J] . Wong TM, Wu S Journal of cardiac surgery. . 2002,第5期

机译：κ阿片受体在心脏预处理中的作用：在心脏手术中的意义。
2. Role of central and peripheral opioid receptors in the cardioprotection of intravenous morphine preconditioning (vol 180, pg 881, 2011) [J] . Lu Y., Dong C., Yu J., Irish journal of medical science . 2016,第2期

机译：中枢和外周阿片受体在静脉吗啡预处理的心脏保护中的作用（第180卷，第881页，2011年）
3. Role of central and peripheral opioid receptors in the cardioprotection of intravenous morphine preconditioning. [J] . Lu Y, Dong C, Yu J, Irish journal of medical science . 2011,第4期

机译：中枢和外周阿片受体在静脉吗啡预处理中的心脏保护作用。
4. Opioid Ligand Binding to Opioid Receptors: Insight and Implications for Peptide Design [C] . Michael J. Ferracane, Jane V. Aldrich American Peptide Symposium . 2015

机译：阿片类配体与阿片受体的结合：肽设计的见解和影响
5. Mechanistic comparison of the signal transduction pathways responsible for cardioprotection induced by myocardial preconditioning or stimulation of the delta-one-opioid receptor. [D] . Fryer, Ryan Michael. 2001

机译：负责心肌预处理或刺激δ一阿片样物质受体引起的心脏保护的信号转导途径的机制比较。
6. Effect of apelin on cardiac contractility in acute reno-vascular hypertension: The role of apelin receptor and kappa opioid receptor heterodimerization [O] . Mahboobeh Yeganeh-Hajahmadi, Hamid Najafipour, Farzaneh Farzaneh, 2018

机译：apelin对急性肾血管性高血压患者心脏收缩的影响：apelin受体和κ阿片受体异二聚体的作用
7. Intrathecal morphine preconditioning induces cardioprotection via activation of delta, kappa, and mu opioid receptors in rats [O] . Irwin MG, Zhang Y, Li R, 2009

机译：鞘内注射吗啡预处理通过激活大鼠δ，κ和μ阿片受体诱导心肌保护作用

Role of kappa opioid receptor in cardioprotection of preconditioning: implications in cardiac surgery.

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