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首页> 外文期刊>Journal of Cancer Research and Clinical Oncology >Overexpression of T lymphoma invasion and metastasis 1 predict renal cell carcinoma metastasis and overall patient survival.
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Overexpression of T lymphoma invasion and metastasis 1 predict renal cell carcinoma metastasis and overall patient survival.

机译：T淋巴瘤浸润和转移的过表达1预测肾细胞癌转移和患者总体生存率。

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摘要

T lymphoma invasion and metastasis 1 (Tiam1) is a metastasis-related gene of T lymphoma that is also involved in the metastasis of a variety of other cancers, but little research has been done yet to test its usefulness as a prognostic marker in renal cell carcinoma (RCC). In the present study, we investigated Tiam1 expression and its prognostic significance in RCC. RCC surgical tissue samples were taken from 136 patients with RCC who had been followed up for 5 years. The Tiam1 expressions in the 136 clinical samples were tested by immunohistochemical assay to find their association with prognostic significance. We found that 93 of 136 (68.4%) paraffin-embedded archival RCC biopsies showed positive expression of Tiam1. Statistical analysis showed that there was significant difference of Tiam1 overexpression in patients categorized according to lymph node metastasis. Patients with higher Tiam1 expression had shorter overall survival time, whereas patients with lower Tiam1 expression had better survival. Multivariate analysis showed that Tiam1 overexpression was an independent prognostic indicator for patient's survival. Our results suggest that Tiam1 protein is a valuable marker of RCC progression. High Tiam1 expression is associated with poor overall survival in patients with RCC.
机译：T淋巴瘤的侵袭和转移1（Tiam1）是与T淋巴瘤的转移相关的基因，它也参与多种其他癌症的转移，但尚未进行任何研究来测试其作为肾细胞预后标志物的作用。癌（RCC）。在本研究中，我们调查了Tiam1在RCC中的表达及其预后意义。 RCC手术组织样本取自136例RCC患者，随访5年。用免疫组织化学法检测136例临床样品中Tiam1的表达，发现其与预后相关。我们发现136例石蜡包埋的RCC活检样本中有93例显示Tiam1阳性表达。统计分析表明，按淋巴结转移分类的患者中，Tiam1过表达的差异显着。 Tiam1表达较高的患者总体生存时间较短，而Tiam1表达较低的患者生存较好。多变量分析表明，Tiam1过表达是患者生存的独立预后指标。我们的结果表明，Tiam1蛋白是RCC进展的重要标志。 Tiam1的高表达与RCC患者的总生存期差有关。

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