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首页> 外文期刊>Journal of child psychology and psychiatry >Shared familial transmission of autism spectrum and attention-deficit/ hyperactivity disorders
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Shared familial transmission of autism spectrum and attention-deficit/ hyperactivity disorders

机译：自闭症谱系的家族性传播和注意力缺陷/多动障碍

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Background To determine whether familial transmission is shared between autism spectrum disorders and attention-deficit/hyperactivity disorder, we assessed the prevalence, rates of comorbidity, and familial transmission of both disorders in a large population-based sample of children during a recent 7 year period. Methods Study participants included all children born to parents with the Kaiser Permanente Northwest (KPNW) Health Plan between 1 January 1998 and 31 December 2004 (n = 35,073). Children and mothers with physician-identified autism spectrum disorders (ASD) and/or attention-deficit/hyperactivity disorder (ADHD) were identified via electronic medical records maintained for all KPNW members. Results Among children aged 6-12 years, prevalence was 2.0% for ADHD and 0.8% for ASD; within those groups, 0.2% of the full sample (19% of the ASD sample and 9.6% of the ADHD sample) had co-occurring ASD and ADHD, when all children were included. When mothers had a diagnosis of ADHD, first born offspring were at 6-fold risk of ADHD alone (OR = 5.02, p <.0001) and at 2.5-fold risk of ASD alone (OR = 2.52, p <.01). Results were not accounted for by maternal age, child gestational age, child gender, and child race. Conclusions Autism spectrum disorders shares familial transmission with ADHD. ADHD and ASD have a partially overlapping diathesis.
机译：背景为了确定自闭症谱系障碍和注意力缺陷/多动障碍之间是否存在家族传播，我们评估了最近7年期间大量基于人口的儿童样本中两种疾病的患病率，合并症发生率和家族传播。方法研究对象包括1998年1月1日至2004年12月31日期间参加西北凯撒永久医疗（KPNW）健康计划的父母所生的所有儿童（n = 35,073）。通过为所有KPNW成员保存的电子病历，识别出患有医师确定的自闭症谱系障碍（ASD）和/或注意力不足/多动症（ADHD）的儿童和母亲。结果6-12岁儿童中，多动症患病率为2.0％，自闭症患病率为0.8％;在这些组中，当包括所有儿童时，全部样本的0.2％（ASD样本的19％和ADHD样本的9.6％）同时存在ASD和ADHD。当母亲被诊断出患有多动症时，第一胎后代的风险仅为单动性痴呆的6倍（OR = 5.02，p <.0001）和单动性焦虑症的2.5倍风险（OR = 2.52，p <.01）。孕产妇年龄，儿童胎龄，儿童性别和儿童种族未考虑结果。结论自闭症谱系障碍与ADHD家族传播。 ADHD和ASD具有部分重叠的素质。

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