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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Effects of 2-deoxy-d-glucose on focal cerebral ischemia in hyperglycemic rats.
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Effects of 2-deoxy-d-glucose on focal cerebral ischemia in hyperglycemic rats.

机译：2-脱氧-d-葡萄糖对高血糖大鼠局灶性脑缺血的影响。

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The authors examined the effects of pretreatment with 2-deoxy-d-glucose (2DG) on the middle cerebral artery occlusion-reperfusion (MCAO/R) model in hyperglycemic rats. Proton magnetic resonance imaging and spectroscopy were used to measure the lesion size, the level of cerebral perfusion deficit, and ratio of lactate to N-acetyl aspartate (NAA) in brain regions. By performing sequential diffusion weighted imaging, gradient echo bolus tracking, steady-state spin echo imaging, and water-suppressed proton magnetic resonance spectroscopy techniques, the time course of the early changes of the lactate/NAA peak ratio and perfusion deficit was examined in hyperglycemic rats undergoing 90-minute MCAO followed by 24-h reperfusion. Compared with the saline-treated hyperglycemic rats, 2DG treatment at 10 minutes before MCAO significantly reduced diffusion weighted imaging hyperintensity by approximately 60% and the lactate/NAA peak ratio by approximately 70% at 4 h after MCAO/R. Both spin echo-measured cerebral blood volume and dynamic gradient echo-relative cerebral blood flow showed that the restoration of blood supply recovered and remained at approximately 80% of baseline during reperfusion in 2DG-treated hyperglycemic rats. These data suggest that inhibition of glucose metabolism by 2DG has a beneficial effect in reducing brain injury and minimizing the production of brain lactate during MCAO/R in hyperglycemic rats.
机译：作者检查了2-脱氧-d-葡萄糖（2DG）预处理对高血糖大鼠大脑中动脉闭塞-再灌注（MCAO / R）模型的影响。使用质子磁共振成像和光谱法测量脑区域的病变大小，脑灌注不足水平以及乳酸与N-乙酰天门冬氨酸（NAA）的比例。通过执行顺序扩散加权成像，梯度回波推注跟踪，稳态自旋回波成像和水抑制质子磁共振波谱技术，可以检查高血糖症中乳酸/ NAA峰比和灌注不足的早期变化的时间过程。大鼠接受90分钟MCAO，然后再进行24小时再灌注。与盐水治疗的高血糖大鼠相比，在MCAO / R后4小时，MCAO之前10分钟的2DG治疗显着降低了弥散加权成像高强度，使乳酸/ NAA峰值比率降低了约60％。自旋回波测量的脑血容量和动态梯度回波相对的脑血流量均表明，在2DG处理的高血糖大鼠中，在再灌注期间血供恢复了并保持在基线的约80％。这些数据表明，在高血糖大鼠的MCAO / R期间，2DG抑制葡萄糖代谢具有减少大脑损伤和最小化脑乳酸产生的有益作用。

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