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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Cardiac arrest/cardiopulmonary resuscitation increases anxiety-like behavior and decreases social interaction.
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Cardiac arrest/cardiopulmonary resuscitation increases anxiety-like behavior and decreases social interaction.

机译：心脏骤停/心肺复苏可增加焦虑样行为并减少社交互动。

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摘要

Advances in medical technology have increased the number of individuals who survive cardiac arrest/cardiopulmonary resuscitation (CPR). This increased incidence of survival has created a population of patients with behavioral and physiologic impairments. We used temperature manipulations to characterize the contribution of central nervous system damage to behavioral deficits elicited by 8 minutes of cardiac arrest/CPR in a mouse model. Once sensorimotor deficits were resolved, we examined anxiety-like behavior with the elevated plus maze and social interaction with an ovariectomized female. We hypothesized that anxiety-like behavior would increase and social interaction would decrease in mice subjected to cardiac arrest/CPR and that these changes would be attributable to central nervous system damage rather than damage to peripheral organs or changes orchestrated by the administration of epinephrine. Mice that were subjected to cardiac arrest/CPR while the peripheral organs, but not the brain, were protected by hypothermia exhibited increased anxiety-like behavior and decreased social interaction, whereas mice with hypothermic brains and peripheral organs during cardiac arrest/CPR did not exhibit behavioral impairments. The present study demonstrates that central nervous system damage from cardiac arrest/CPR results in increased anxiety and decreased social interaction and that these behavioral changes are not attributed to underlying sensorimotor deficits, dynamics of arrest and CPR, or peripheral organ damage.
机译：医疗技术的进步增加了在心脏骤停/心肺复苏（CPR）中幸存下来的人数。这种增加的生存率已经造成了行为和生理障碍的患者群体。我们使用温度操纵来表征中枢神经系统损伤对小鼠模型中8分钟的心脏骤停/ CPR引起的行为缺陷的影响。一旦感觉运动功能障碍得到解决，我们就检查了迷宫般的行为，以及迷宫切除后的女性以及与之互动的社交活动。我们假设在经历心脏骤停/ CPR的小鼠中，类似焦虑的行为会增加，社交互动会减少，并且这些变化将归因于中枢神经系统损害，而不是对周围器官的损害或肾上腺素管理导致的变化。经受过心脏骤停/ CPR而处于低温状态的外围器官而不是大脑受到保护的小鼠表现出增加的焦虑样行为并减少了社交互动，而在心脏骤停/ CPR期间具有低温大脑和外围器官的小鼠则没有表现出焦虑感行为障碍。本研究表明，心脏骤停/ CPR引起的中枢神经系统损害会导致焦虑增加和社交互动减少，并且这些行为变化不归因于潜在的感觉运动缺陷，骤停和CPR动力学或周围器官损害。

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