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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model.
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Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model.

机译：在大鼠永久性阻塞模型中，静脉注射二甲基亚砜对缺血进程的影响。

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摘要

Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant. We (1) tested the neuroprotective potential of DMSO at different time windows on infarct size using 2,3,5-triphenyltetrazolium staining and (2) investigated the effects of DMSO on ischemia evolution using quantitative diffusion and perfusion imaging in a permanent middle cerebral artery occlusion (MCAO) model in rats. In experiment 1, DMSO treatment (1.5 g/kg intravenously over 3 h) reduced infarct volume 24 h after MCAO by 65% (P<0.00001) when initiated 20 h before MCAO, by 44% (P=0.0006) when initiated 1 h after MCAO, and by 17% (P=0.11) when started 2 h after MCAO. Significant infarct reduction was also observed after a 3-day survival in animals treated 1 h after MCAO (P=0.005). In experiment 2, treatment was initiated 1 h after MCAO and maps for cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) were acquired before treatment and then every 30 mins up to 4 h. Cerebral blood flowcharacteristics and CBF-derived lesion volumes did not differ between treated and untreated animals, whereas the ADC-derived lesion volume essentially stopped progressing during DMSO treatment, resulting in a persistent diffusion/perfusion mismatch. This effect was mainly observed in the cortex. Our data suggest that DMSO represents an interesting candidate for acute stroke treatment.
机译：二甲基亚砜（DMSO）具有多种生物学作用，可作为神经保护剂发挥作用。我们（1）使用2,3,5-三苯基四唑鎓染色法测试了DMSO在不同时间窗对梗死面积的神经保护能力，（2）使用定量扩散和灌注成像在永久性大脑中动脉中研究了DMSO对缺血演变的影响。大鼠闭塞（MCAO）模型。在实验1中，DMSO处理（在3小时内静脉注射1.5 g / kg）在MCAO发生前20 h，在MCAO后24 h减少了65％（P <0.00001）的梗死体积，在1 h发生后降低了44％（P = 0.0006）在MCAO之后开始，并且在MCAO之后2小时开始时降低了17％（P = 0.11）。 MCAO治疗1小时后的动物存活3天后，也观察到明显的梗塞减少（P = 0.005）。在实验2中，治疗在MCAO后1小时开始，并在治疗前获取脑血流量（CBF）和表观扩散系数（ADC）图，然后每30分钟进行一次，直至4 h。在治疗和未治疗的动物之间，脑血流特征和CBF引起的病变体积没有差异，而在DMSO治疗期间，ADC引起的病变体积基本上停止了进展，导致持续的扩散/灌注失配。该效应主要在皮质中观察到。我们的数据表明DMSO代表了急性卒中治疗的有趣候选者。

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