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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Development of a tracer kinetic plasma input model for (R)-(11C)PK11195 brain studies.
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Development of a tracer kinetic plasma input model for (R)-(11C)PK11195 brain studies.

机译：（R）-（11C）PK11195脑研究的示踪动力学血浆输入模型的开发。

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(R)-[(11)C]PK11195 ([1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl]-3-isoquinoline carboxamide) is a ligand for the peripheral benzodiazepine receptor, which, in the brain, is mainly expressed on activated microglia. Using both clinical studies and Monte Carlo simulations, the aim of this study was to determine which tracer kinetic plasma input model best describes (R)-[(11)C]PK11195 kinetics. Dynamic positron emission tomography (PET) scans were performed on 13 subjects while radioactivity in arterial blood was monitored online. Discrete blood samples were taken to generate a metabolite corrected plasma input function. One-tissue, two-tissue irreversible, and two-tissue reversible compartment models, with and without fixing K(1)/k(2) ratio, k(4) or blood volume to whole cortex values, were fitted to the data. The effects of fixing parameters to incorrect values were investigated by varying them over a physiologic range and determining accuracy and reproducibility of binding potential and volume of distribution using Monte Carlo simulations. Clinical data showed that a two-tissue reversible compartment model was optimal for analyzing (R)-[(11)C]PK11195 PET brain studies. Simulations showed that fixing the K(1)/k(2) ratio of this model provided the optimal trade-off between accuracy and reproducibility. It was concluded that a two-tissue reversible compartment model with K(1)/k(2) fixed to whole cortex value is optimal for analyzing (R)-[(11)C]PK11195 PET brain studies.
机译：（R）-[（11）C] PK11195（[1-（2-氯苯基）-N-甲基-N-（1-甲基丙基] -3-异喹啉羧酰胺）是外围苯并二氮杂receptor受体的配体，通过临床研究和蒙特卡洛模拟，本研究的目的是确定哪种示踪剂动力学血浆输入模型最能描述（R）-[（11）C] PK11195动力学。对13名受试者进行了发射断层扫描（PET）扫描，同时在线监测了动脉血中的放射性，并采集了离散的血样以生成代谢物校正的血浆输入功能，其中有一个组织，两个组织不可逆和两个组织可逆隔室模型固定和不固定K（1）/ k（2）比率，k（4）或血容量与整个皮层值的关系，将其拟合到数据中，并通过在生理上改变参数来将参数固定为不正确的值的效果范围和确定结合电位的准确性和可重复性和蒙特卡洛模拟的分布量。临床数据显示，两组织可逆隔室模型最适合分析（R）-[（11）C] PK11195 PET脑研究。仿真表明，固定此模型的K（1）/ k（2）比可在精度和可重复性之间提供最佳平衡。结论是，将K（1）/ k（2）固定到整个皮质值的两组织可逆隔室模型是分析（R）-[（11）C] PK11195 PET脑研究的最佳选择。

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