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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Fuelling cerebral activity in exercising man.
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Fuelling cerebral activity in exercising man.

机译：在锻炼男人时助长大脑活动。

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摘要

The metabolic response to brain activation in exercise might be expressed as the cerebral metabolic ratio (MR; uptake O2/glucose + 1/2 lactate). At rest, brain energy is provided by a balanced oxidation of glucose as MR is close to 6, but activation provokes a 'surplus' uptake of glucose relative to that of O2. Whereas MR remains stable during light exercise, it is reduced by 30% to 40% when exercise becomes demanding. The MR integrates metabolism in brain areas stimulated by sensory input from skeletal muscle, the mental effort to exercise and control of exercising limbs. The MR decreases during prolonged exhaustive exercise where blood lactate remains low, but when vigorous exercise raises blood lactate, the brain takes up lactate in an amount similar to that of glucose. This lactate taken up by the brain is oxidised as it does not accumulate within the brain and such pronounced brain uptake of substrate occurs independently of plasma hormones. The 'surplus' of glucose equivalents taken up by the activated brain may reach approximately 10 mmol, that is, an amount compatible with the global glycogen level. It is suggested that a low MR predicts shortage of energy that ultimately limits motor activation and reflects a biologic background for 'central fatigue'.
机译：运动对脑部激活的代谢反应可能表示为脑部代谢率（MR;摄取O2 /葡萄糖+ 1/2乳酸）。静止时，当MR接近6时，大脑的能量由葡萄糖的平衡氧化提供，但是激活会引起相对于O2的葡萄糖“过量”摄取。轻度运动时MR保持稳定，而运动量大时则可降低30％至40％。 MR整合了骨骼肌的感觉输入，运动和控制肢体的精神投入所刺激的大脑区域的新陈代谢。在长时间的力竭运动（血液中乳酸水平仍然较低）下，MR会降低，但是当剧烈运动会增加血液中的乳酸水平时，大脑吸收的乳酸量与葡萄糖相似。大脑吸收的乳酸会被氧化，因为它不会在大脑中蓄积，并且这种明显的大脑底物吸收与血浆激素无关。被激活的大脑吸收的葡萄糖当量的“剩余”可能达到约10 mmol，即与总体糖原水平兼容的量。建议低MR预测能量不足，这最终会限制电机激活，并反映出“中央疲劳”的生物学背景。

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