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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Progesterone administration during reperfusion, but not preischemia alone, reduces injury in ovariectomized rats.
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Progesterone administration during reperfusion, but not preischemia alone, reduces injury in ovariectomized rats.

机译：再灌注期间给予黄体酮可减轻卵巢切除大鼠的损伤，但不能单独给予缺血前治疗。

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摘要

Although progesterone is neuroprotective in traumatic brain injury, its efficacy in stroke is unclear. The authors determined whether there are infarction differences after middle cerebral artery occlusion (MCAO) in ovariectomized rats treated acutely with progesterone before MCAO or both pre- and postischemia. Rats received vehicle, 5 (P5), 10 (P10), or 20 (P20) mg/kg progesterone intraperitoneally 30 minutes before MCAO. In another cohort, animals received vehicle or 5 (P5R) mg/kg progesterone intraperitoneally 30 minutes before MCAO, at reperfusion initiation, and at 6-hour reperfusion. Animals underwent 2-hour MCAO by the intraluminal filament technique, followed by 22-hour reperfusion. Cortical (CTX) and caudate-putamen (CP) infarctions were determined by 2,3,5-triphenyltetrazolium chloride staining and digital image analysis. End-ischemic and early reperfusion regional cerebral blood flow (CBF) was measured by [ C]-iodoantipyrine quantitative autoradiography in vehicle- or progesterone (5 mg/kg)-treated rats. Cortical infarction (% contralateral CTX) was 31 +/- 30% (vehicle), 39 +/- 23% (P5), 41 +/- 14% (P10), and 28 +/- 20% (P20). Caudate-putamen infarction (% contralateral CP) was 45 +/- 37% (vehicle), 62 +/- 34% (P5), 75 +/- 17% (P10), and 52 +/- 30% (P20). In vehicle and P5R groups, CTX infarction was 37 +/- 20% and *20 +/- 17%, respectively (* < 0.05 from vehicle). In vehicle and P5R groups, CP infarction was 63 +/- 26% and 43 +/- 29%, respectively. End-ischemic regional CBF and CBF recovery during initial reperfusion was unaffected by progesterone treatment. These data suggest that progesterone administration both before MCAO and during reperfusion decreases ischemic brain injury.
机译：尽管孕酮在脑外伤中具有神经保护作用，但其在中风方面的疗效尚不清楚。这组作者确定了在MCAO之前或缺血前和缺血后用孕酮急性治疗的卵巢切除的大鼠中脑动脉闭塞（MCAO）后是否存在梗塞差异。在MCAO前30分钟，大鼠腹膜内接受了5、5（P5），10（P10）或20（P20）孕酮/孕激素。在另一个队列中，动物在MCAO之前30分钟，再灌注开始和6小时再灌注时腹膜内接受媒介物或5（P5R）mg / kg孕酮。通过腔内细丝技术对动物进行2小时MCAO，然后进行22小时再灌注。皮质（CTX）和尾状-丘脑（CP）梗死是通过2,3,5-三苯基四唑氯化物染色和数字图像分析确定的。通过[C]-碘安替比林定量放射自显影术在媒介物或孕酮（5 mg / kg）治疗的大鼠中测量局部缺血和早期再灌注区域脑血流量（CBF）。皮质梗死（对侧CTX百分比）为31 +/- 30％（车辆），39 +/- 23％（P5），41 +/- 14％（P10）和28 +/- 20％（P20）。尾状丘脑梗塞（对侧CP百分比）为45 +/- 37％（车辆），62 +/- 34％（P5），75 +/- 17％（P10）和52 +/- 30％（P20） 。在媒介物和P5R组中，CTX梗死分别为37 +/- 20％和* 20 +/- 17％（媒介物* * 0.05）。在媒介物和P5R组中，CP梗死分别为63 +/- 26％和43 +/- 29％。孕酮治疗不影响初次再灌注期间局部缺血区域的CBF和CBF的恢复。这些数据表明孕激素在MCAO之前和再灌注期间均可减少缺血性脑损伤。

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