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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Metabolic imaging of human cognition: an fMRI/1H-MRS study of brain lactate response to silent word generation.
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Metabolic imaging of human cognition: an fMRI/1H-MRS study of brain lactate response to silent word generation.

机译:人类认知的代谢成像:fMRI / 1H-MRS研究乳酸对无声单词生成的反应。

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摘要

Proton magnetic resonance spectroscopy (1H-MRS) allows in vivo assessment of the metabolism related to human brain functions. Visual, auditory, tactile, and motor stimuli induce a temporary increase in the brain lactate level, which may act as a rapid source of energy for the activated neurons. The authors studied the metabolism of the frontal lobes during cognitive stimulation and measured local lactate levels with standard 1H-MRS, after localizing the activated area by functional MRI. Lactate levels were monitored while the subjects either silently listed numbers (baseline) or performed a silent word-generation task (stimulus-activation). The cognitive stimulus-activation produced a 50% increase in the brain lactate level in the left inferior frontal gyrus. The results show that metabolic imaging of neuronal activity related to cognition is possible using 1H-MRS.
机译:质子磁共振波谱(1H-MRS)可以在体内评估与人脑功能相关的代谢。视觉,听觉,触觉和运动刺激会引起大脑乳酸水平的暂时升高,这可能是激活神经元的快速能量来源。作者研究了认知刺激过程中额叶的代谢,并在通过功能性MRI定位激活区域后,用标准的1H-MRS测量了局部乳酸水平。在受试者静默列出数字(基线)或执行静默单词生成任务(刺激激活)时,监测乳酸水平。认知刺激激活使左下额回的大脑乳酸水平增加了50%。结果表明,使用1H-MRS可以进行与认知有关的神经元活动的代谢成像。

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