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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Mild to moderate hyperthermia does not worsen outcome after severe intracerebral hemorrhage in rats.
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Mild to moderate hyperthermia does not worsen outcome after severe intracerebral hemorrhage in rats.

机译：在大鼠严重脑出血后，轻度至中度高温不会使预后恶化。

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Hyperthermia worsens outcome in clinical and experimental studies of ischemic stroke. Thus, we tested whether hyperthermia aggravates intracerebral hemorrhage (ICH) in rats. A striatal hemorrhage was produced via an infusion of bacterial collagenase. In a preliminary experiment, we compared brain and core temperatures (via telemetry) during heating (infrared lamp). The brain temperature rise exceeded that produced by enforced core hyperthermia, which was used subsequently. In these experiments up to three hyperthermia conditions (versus normothermia) were tested including: hyperthermia (>38.5 degrees C) over the first (HYP-1) or second 24 h period (HYP-2) after ICH and 3 h of 40 degrees C hyperthermia starting 12 h after ICH (HYP-3). The HYP-1, HYP-2, and HYP-3 treatments did not affect functional deficits (e.g., spontaneous forelimb use, skilled reaching) or the volume of injury at 30 days. Furthermore, the HYP-1 treatment did not aggravate injury or deficits at 7 days. Bleeding and inflammation, which contribute to pathology, were not significantly altered by HYP-1 and HYP-3 treatments. Bleeding was assessed at 1 day, and macrophages and neutrophils were counted at 2 and 4 days. Accordingly, hyperthermia, under the present conditions, did not worsen outcome after striatal ICH.
机译：热疗会使缺血性中风的临床和实验研究的结局恶化。因此，我们测试了体温过高是否会加剧大鼠的脑出血（ICH）。通过注入细菌胶原酶产生纹状体出血。在初步实验中，我们比较了加热（红外灯）期间的大脑和核心温度（通过遥测）。脑温升高超过了强制性核心体温过高所产生的温度，后来又采用了这种方法。在这些实验中，最多测试了三种热疗条件（相对于正常体温），包括：ICH后第一个（HYP-1）或第二个24 h期间（> 38.5°C）以及40°C下的3 h ICH（HYP-3）后12小时开始热疗。 HYP-1，HYP-2和HYP-3治疗不会影响功能缺陷（例如，自发前肢使用，熟练达到）或30天时的损伤程度。此外，HYP-1治疗在第7天并未加重伤害或缺陷。 HYP-1和HYP-3治疗不会明显改变导致病理的出血和炎症。在第1天评估出血，在第2和4天计数巨噬细胞和中性粒细胞。因此，在目前情况下，高热并不会加重纹状体脑出血的预后。

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