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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Asymptomatic Intracerebral Hemorrhage May Worsen Clinical Outcomes in Acute Ischemic Stroke Patients Undergoing Thrombectomy
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Asymptomatic Intracerebral Hemorrhage May Worsen Clinical Outcomes in Acute Ischemic Stroke Patients Undergoing Thrombectomy

机译：无症状的脑内出血可能使血液切除术急性缺血性卒中患者的临床结果恶化

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Background: Asymptomatic intracerebral hemorrhage (AICH) is a common phenomenon in patients with acute ischemic stroke (AIS) who were treated with endovascular thrombectomy (ET). This study aimed to evaluate the clinical effects of AICH and its risk factors in this patient population. Methods: This observational study was based on a prospective registry study. AIS patients with large-vessel occlusion in the anterior circulation and treated with ET were recruited. During thrombectomy procedures, intra-arterial infusion of thrombolytics or antiplatelet and permanent stenting were used as remedial therapies. The primary outcome was the overall distribution of modified Rankin scale (mRS) 90 days after ET. Results: This study included 102 patients (61.1 +/- 12.7 years old), in whom 39 patients (38.2%) experienced AICH. At 90-day follow-up, the median mRS was 2 (interquartile range [IQR] 0-3) for patients without AICH and 4 (IQR 2-6) for those with AICH (adjusted P=.005). Fourteen patients with AICH and 7 patients without AICH died, which was significantly different (35.9% versus 11.1%, adjusted P=.015). Thirty-nine patients (61.9%) without AICH and 14 patients (35.9%) with AICH achieved functional independence at 3-month follow-up (adjusted P=.117). The length of intensive care unit staying was 5 days (IQR 2-10) in patients without AICH and 8 days (IQR 3-19) in those with AICH (adjusted P=.840). In multivariate analysis, lower Alberta Stroke Program Early CT Score (ASPECTS) (adjusted P=.003) and adjunctively intra-arterial thrombolysis (adjusted P=.016) were independently associated with AICH. Conclusions: In AIS patients treated with ET AICH appears to be associated with worse functional outcomes and high mortality. Lower ASPECTS and adjectively intra-arterial thrombolysis were independent risk factors of AICH.
机译：背景：无症状脑内出血（AICH）是急性缺血性卒中（AIS）患者的常见现象，血管内血管切除术（ET）治疗。本研究旨在评估AICH及其危险因素在该患者群体中的临床影响。方法：该观察研究基于预期注册表研究。招募了患有大血管闭塞的AIS患者，并招募了ET治疗。在血液切除术期间，使用溶栓或抗血栓或永粘型和永久支架的动脉内输注作为补救疗法。主要结果是ET 90天改进的Rankin规模（MRS）的总体分布。结果：本研究包括102名患者（61.1 +/- 12.7岁），其中39名患者（38.2％）经历过AICH。在90天的随访中，MRS为2（IQRILE）为2（IQR级），对于没有AICH的患者，4名（IQR 2-6）的患者（调整为P = .005）。 14名患有AICH和7例没有AICH的患者死亡，显着差异（35.9％，调整为p = .015）。没有AICH和14名患者（61.9％），14名患者（35.9％）在3个月随访时实现了功能独立（调整的P = .117）。在没有AICH的患者和8天（IQR 3-19）中，密集护理单位住宿的长度为5天（IQR 2-10），其中8天（IQR 3-19）（调整为P = .840）。在多变量分析中，较低的alberta中风程序早期CT得分（方面）（调节p = .003）和升级动脉内溶栓（调节的p = .016）与AICH独立相关。结论：在AIS患者中，治疗的患者似乎与更严重的功能结果和高死亡率有关。较低的方面和形容词内动脉溶栓是AICH的独立危险因素。

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