Induction of heme oxygenase-1 and major histocompatibility complex antigens in transient forebrain ischemia.

Matsuoka Y; Kitamura Y; Okazaki M; Sakata M; Tsukahara T; Taniguchi T

首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Induction of heme oxygenase-1 and major histocompatibility complex antigens in transient forebrain ischemia.

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Induction of heme oxygenase-1 and major histocompatibility complex antigens in transient forebrain ischemia.

机译：短暂性前脑缺血中血红素加氧酶-1和主要组织相容性复合抗原的诱导。

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Recent studies strongly suggest that oxidative stresses participate in ischemia/reperfusion-induced neurodegeneration. In addition, heme oxygenase (HO) and major histocompatibility complex (MHC) antigens serve as functional molecules against oxidative stress and as self-recognition markers in the immune system, respectively. In this study, we examined the induction of HO and MHC antigens in the rat hippocampus after transient forebrain ischemia. The protein level of HO-1 was significantly enhanced after an episode of ischemia. After ischemia, HO-1 expression was observed early but transiently in the CA1 pyramidal neurons and later but continuously in glial cells. Glial cells expressing HO-1 were predominantly ameboid microglia, but not astrocytes. Ameboid microglia expressing HO-1 were predominantly localized with MHC class II antigens. These results indicate that (1) HO-1 expression in CA1 pyramidal neurons may be harmful, and (2) ischemia induces HO-1 in ameboid microglia that express MHC class II antigens, indicating a very specific microglial stress protein response.

机译：最近的研究强烈表明氧化应激参与缺血/再灌注诱导的神经变性。此外，血红素加氧酶（HO）和主要组织相容性复合物（MHC）抗原分别充当抵抗氧化应激的功能分子和免疫系统中的自我识别标记。在这项研究中，我们检查了短暂性前脑缺血后大鼠海马中HO和MHC抗原的诱导。局部缺血发作后，HO-1的蛋白水平显着提高。缺血后，在CA1锥体神经元中早期但短暂地观察到HO-1表达，后来在胶质细胞中持续观察到。表达HO-1的神经胶质细胞主要是类淀粉样小胶质细胞，而不是星形胶质细胞。表达HO-1的变形虫小胶质细胞主要定位在MHC II类抗原上。这些结果表明（1）HO-1在锥体锥体神经元中的表达可能是有害的，并且（2）缺血在表达MHC II类抗原的类小胶质细胞中诱导HO-1，这表明非常特殊的小胶质细胞应激蛋白反应。

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《Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism》 |1998年第8期|共9页
作者
Matsuoka Y; Kitamura Y; Okazaki M; Sakata M; Tsukahara T; Taniguchi T;
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正文语种 eng
中图分类神经病学;内分泌腺疾病及代谢病;
关键词
Heme Oxygenase Decyclizing biosynthesis; Hippocampus; Ischemic Attack; Transient enzymology; 海马; 主要组织相容性复合物;

机译：Heme Oxygenase Decyclizing biosynthesis;Hippocampus;Ischemic Attack;Transient enzymology;海马;主要组织相容性复合物;

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1. Induction of heme oxygenase-1 and major histocompatibility complex antigens in transient forebrain ischemia. [J] . Matsuoka Y, Kitamura Y, Okazaki M, Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism . 1998,第8期

机译：短暂性前脑缺血中血红素加氧酶-1和主要组织相容性复合抗原的诱导。
2. Phosphorylation of c-Jun and its localization with heme oxygenase-1 and cyclooxygenase-2 in CA1 pyramidal neurons after transient forebrain ischemia. [J] . Matsuoka Y, Okazaki M, Zhao H, Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism . 1999,第11期

机译：短暂性前脑缺血后CA1锥体神经元中c-Jun的磷酸化及其在血红素加氧酶-1和环加氧酶-2中的定位。
3. Induction of heme oxygenase protein protects neurons in cortex and striatum, but not in hippocampus, against transient forebrain ischemia. [J] . Takizawa S, Hirabayashi H, Matsushima K, Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism . 1998,第5期

机译：血红素加氧酶蛋白的诱导可保护皮层和纹状体中的神经元，但不能保护海马中的神经元免于短暂性前脑缺血。
4. Pegylated hemin, a water-soluble micelle with therapeutic potential against ischemia-reperfusion injury via induction of heme oxygenase-1 [C] . Jun Fang, Haibo Qin, Takahiro Seki, Annual meeting exposition of the Controlled Release Society . 2011

机译：聚乙二醇化的血红素，一种水溶性胶束，具有通过诱导血红素加氧酶-1对抗缺血再灌注损伤的治疗潜力
5. Increased density of class I major histocompatibility complex antigens and decreased density of T-cell differentiation antigens in the early stages of T-cell activation [D] . 松井良樹 1988

机译：在T细胞活化的早期，I类主要组织相容性复合抗原的密度增加，而T细胞分化抗原的密度降低
6. Autocrine induction of major histocompatibility complex class I antigen expression results from induction of beta interferon in oncogene-transformed BALB/c-3T3 cells. [O] . M K Offermann, D V Faller 1989

机译：自分泌诱导的主要组织相容性复合体I类抗原表达是由癌基因转化的BALB / c-3T3细胞中的β干扰素诱导产生的。
7. Induction of Heme Oxygenase-1 and Major Histocompatibility Complex Antigens in Transient Forebrain Ischemia [O] . Yasuji Matsuoka, Yoshihisa Kitamura, Mitsuhiro Okazaki, 1998

机译：血红素氧酶-1和主要组织相容性复合物抗原在短暂前脑缺血中的诱导
8. HLA(Human Leukocyte Antigen): The Major Histocompatibility Complex. Immunogenetics of HLA Antigens [R] . Johnson, A. H., Hartzman, R. J., Robinson, M. A. 1984

机译：HLa（人白细胞抗原）：主要组织相容性复合物。 HLa抗原的免疫遗传学

Induction of heme oxygenase-1 and major histocompatibility complex antigens in transient forebrain ischemia.

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