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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Crossed cerebellar diaschisis after stroke: can perfusion-weighted MRI show functional inactivation?
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Crossed cerebellar diaschisis after stroke: can perfusion-weighted MRI show functional inactivation?

机译：脑卒中后交叉小脑透析：MRI灌注加权能显示功能失活吗？

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摘要

In this study, we aimed to assess the detection of crossed cerebellar diaschisis (CCD) following stroke by perfusion-weighted magnetic resonance imaging (PW-MRI) in comparison with positron emission tomography (PET). Both PW-MRI and 15O-water-PET were performed in acute and subacute hemispheric stroke patients. The degree of CCD was defined by regions of interest placed in the cerebellar hemispheres ipsilateral (I) and contralateral (C) to the supratentorial lesion. An asymmetry index (AI=C/I) was calculated for PET-cerebral blood flow (CBF) and MRI-based maps of CBF, cerebral blood volume (CBV), mean transit time (MTT), and time to peak (TTP). The resulting AI values were compared by Bland-Altman (BA) plots and receiver operating characteristic analysis to detect the degree and presence of CCD. A total of 26 imaging procedures were performed (median age 57 years, 20/26 imaged within 48 hours after stroke). In BA plots, all four PW-MRI maps could not reliably reflect the degree of CCD. In receiver operating characteristic analysis for detection of CCD, PW-CBF performed poorly (accuracy 0.61), whereas CBV, MTT, and TTP failed (accuracy <0.60). On the basis of our findings, PW-MRI at 1.5 T is not suited to depict CCD after stroke.
机译：在这项研究中，我们的目的是通过与传统的正电子发射断层扫描（PET）相比，通过灌注加权磁共振成像（PW-MRI）评估中风后交叉小脑透析（CCD）的检测。 PW-MRI和15O-water-PET均在急性和亚急性半球性卒中患者中进行。 CCD的程度由位于小脑上皮病变同侧（I）和对侧（C）的小脑半球的相关区域定义。计算PET脑血流量（CBF）和基于MRI的CBF，脑血容量（CBV），平均通过时间（MTT）和到达峰值时间（TTP）的图的不对称指数（AI = C / I） 。通过Bland-Altman（BA）图和接收器工作特性分析比较所得的AI值，以检测CCD的程度和存在。总共进行了26次成像程序（中位年龄57岁，卒中后48小时内成像的20/26）。在BA图中，所有四个PW-MRI图都不能可靠地反映CCD的程度。在用于检测CCD的接收器工作特性分析中，PW-CBF表现较差（精度为0.61），而CBV，MTT和TTP则失败（精度<0.60）。根据我们的发现，1.5 T的PW-MRI不适合描绘卒中后的CCD。

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