Tetraplex DNA specific ligands based on the fluorenone-carboxamide scaffold.

Alcaro S; Artese A; Iley JN; Maccari R; Missailidis S; Ortuso F; Ottana R; Ragazzon P; Vigorita MG

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Tetraplex DNA specific ligands based on the fluorenone-carboxamide scaffold.

机译：基于芴酮羧酰胺支架的Tetraplex DNA特异性配体。

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A series of fluorenone-carboxamide compounds was analyzed with regard to DNA binding properties by UV spectroscopy and competition dialysis methods. The morpholino derivative 10 provided interesting results in terms of affinity and specificity toward the DNA G-tetraplex structures. Interactions against this target were evaluated by a comparative molecular modeling study in agreement with the experimental data, proposing a model for the rational design of new agents with potent and selective DNA tetraplex binding properties.

机译：通过紫外光谱法和竞争渗析法分析了一系列芴酮-羧酰胺化合物的DNA结合特性。吗啉代衍生物10在对DNA G-四链体结构的亲和力和特异性方面提供了有趣的结果。通过与实验数据相一致的比较分子建模研究，评估了针对该目标的相互作用，从而为合理设计具有有效和选择性DNA四链体结合特性的新试剂提供了模型。

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《Bioorganic and Medicinal Chemistry Letters》 |2007年第9期|共6页
作者
Alcaro S; Artese A; Iley JN; Maccari R; Missailidis S; Ortuso F; Ottana R; Ragazzon P; Vigorita MG;
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正文语种 eng
中图分类药学;生物化学;
关键词
DNA; fluorenone; binding; Drug Interactions; experiment; 药物相互作用;

机译：DNA;fluorenone;binding;Drug Interactions;experiment;药物相互作用;

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专利

1. Tetraplex DNA specific ligands based on the fluorenone-carboxamide scaffold. [J] . Alcaro S, Artese A, Iley JN, Bioorganic and Medicinal Chemistry Letters . 2007,第9期

机译：基于芴酮羧酰胺支架的Tetraplex DNA特异性配体。
2. Cyclic perylene diimide: Selective ligand for tetraplex DNA binding over double stranded DNA [J] . Suresh Vasimalla, Shinobu Sato, Fuminori Takenaka, Bioorganic and medicinal chemistry . 2017,第24期

机译：循环丙烯二酰亚胺：选择性配体，用于四卷DNA与双链DNA相结合
3. Design of tetraplex specific ligands: cyclic naphthalene diimide [J] . Yugo Esaki, Monirul Islam, Satoshi Fujii, Chemical Communications . 2014,第45期

机译：四重体特定配体的设计：环萘二酰亚胺
4. Modified naphthalene diimide as a suitable tetraplex DNA ligand: Application to cancer diagnosis and anti-cancer drug [C] . Shigeori Takenaka International conference on nano-bio sensing, imaging, and spectroscopy 2017 . 2017

机译：改性萘二酰亚胺作为合适的四重DNA配体：在癌症诊断和抗癌药物中的应用
5. Design of ligands for sequence-specific recognition of the minor-major grooves of DNA. [D] . Szewczyk, Jason W. 1999

机译：配体的设计，用于序列特异性识别DNA的次要凹槽。
6. Polyethylene glycol derivatives of base and sequence specific DNA ligands: DNA interaction and application for base specific separation of DNA fragments by gel electrophoresis. [O] . W Müller, I Hattesohl, H J Schuetz, 1981

机译：碱基和序列特异性DNA配体的聚乙二醇衍生物：DNA相互作用以及通过凝胶电泳对DNA片段进行碱基特异性分离的应用。
7. Polyethylene glycol derivatives of base and sequence specific DNA ligands: DNA interaction and application for base specific separation of DNA fragments by gel electrophoresis. [O] . Müller, W, Hattesohl, I, Schuetz, H J, 1981

机译：碱基和序列特异性DNA配体的聚乙二醇衍生物：DNA相互作用以及通过凝胶电泳对DNA片段进行碱基特异性分离的应用。

Tetraplex DNA specific ligands based on the fluorenone-carboxamide scaffold.

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