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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >4D flow MRI for intracranial hemodynamics assessment in Alzheimer's disease
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4D flow MRI for intracranial hemodynamics assessment in Alzheimer's disease

机译：4D流MRI在阿尔茨海默氏病颅内血流动力学评估中的应用

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摘要

Cerebral blood flow, arterial pulsation, and vasomotion play important roles in the transport of waste metabolites out of the brain. Impaired vasomotion results in reduced driving force for the perivascular/glymphatic clearance of beta-amyloid. Noninvasive cerebrovascular characteristic features that potentially assess these transport mechanisms are mean blood flow (MBF) and pulsatility index (PI). In this study, 4D flow MRI was used to measure intra-cranial flow features, particularly MBF, PI, resistive index (RI) and cross-sectional area in patients with Alzheimer's disease (AD), mild cognitive impairment and in age matched and younger cognitively healthy controls. Three-hundred fourteen subjects participated in this study. Volumetric, time-resolved phase contrast (PC) MRI data were used to quantify hemodynamic parameters from 11 vessel segments. Anatomical variants of the Circle of Willis were also cataloged. The AD population reported a statistically significant decrease in MBF and cross-sectional area, and also an increase in PI and RI compared to age matched cognitively healthy control subjects. The 4D flow MRI technique used in this study provides quantitative measurements of intracranial vessel geometry and the velocity of flow. Cerebrovascular characteristics features of vascular health such as pulsatility index can be extracted from the 4D flow MRI data.
机译：脑血流，动脉搏动和血管运动在废物代谢产物从大脑中的运输中起重要作用。血管舒张功能障碍导致β-淀粉样蛋白的血管周围/淋巴清除的驱动力降低。潜在评估这些转运机制的非侵入性脑血管特征是平均血流量（MBF）和搏动指数（PI）。在这项研究中，使用4D流动MRI来测量阿尔茨海默病（AD），轻度认知障碍以及年龄相匹配且更年轻的患者的颅内血流特征，尤其是MBF，PI，抵抗指数（RI）和横截面积认知健康对照。 341名受试者参加了这项研究。体积，时间分辨相衬（PC）MRI数据用于量化11个血管段的血液动力学参数。威利斯环的解剖变异也被分类。与年龄相匹配的认知健康对照组相比，AD人群报告MBF和横截面积显着降低，PI和RI升高。本研究中使用的4D流MRI技术可定量测量颅内血管的几何形状和流速。可以从4D流MRI数据中提取诸如脉搏指数等血管健康的脑血管特征。

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