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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Effects of hypoglycemia on functional magnetic resonance imaging response to median nerve stimulation in the rat brain.
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Effects of hypoglycemia on functional magnetic resonance imaging response to median nerve stimulation in the rat brain.

机译：低血糖对大鼠大脑中位神经刺激的功能磁共振成像反应的影响。

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The authors studied the effects of a standardized mild-moderate hypoglycemic stimulus (glucose clamp) on brain functional magnetic resonance imaging (fMRI) responses to median nerve stimulation in anesthetized rats. In the baseline period (plasma glucose 6.6 +/- 0.3 mmol/L), the MR signal changes induced by median nerve activation were determined within a fixed region of the somatosensory cortex from preinfusion activation maps. Subsequently, insulin and a variable glucose infusion were administered to decrease plasma glucose. The goal was to produce a stable hypoglycemic plateau (2.8 +/- 0.2 mmol/L) for 30 minutes. Thereafter, plasma glucose was restored to euglycemic levels (6.0 +/- 0.3 mmol/L). In the early phase of insulin infusion (15 to 30 minutes), before hypoglycemia was reached (4.7 +/- 0.3 mmol/L), the activation signal was unchanged. However, once the hypoglycemic plateau was achieved, the activation signal was significantly decreased to 57 +/- 6% of the preinfusion value. Control regions in the brain that were not activated showed no significant changes in MR signal intensity. Upon return to euglycemia, the activation signal change increased to within 10% of the original level. No significant activation changes were noted during euglycemic hyperinsulinemic clamp experiments. The authors concluded that fMRI can detect alterations in cerebral function because of insulin-induced hypoglycemia. The signal changes observed in fMRI activation experiments were sensitive to blood glucose levels and might reflect increases in brain metabolism that are limited by substrate deprivation during hypoglycemia.
机译：作者研究了标准化的轻度-中度降血糖刺激（葡萄糖钳位）对麻醉大鼠大脑功能磁共振成像（fMRI）对中位神经刺激的反应的影响。在基线期（血浆葡萄糖6.6 +/- 0.3 mmol / L），根据输液前激活图在体感皮层的固定区域内确定了中位神经激活引起的MR信号变化。随后，给予胰岛素和可变葡萄糖输注以降低血浆葡萄糖。目标是在30分钟内产生稳定的降血糖平台（2.8 +/- 0.2 mmol / L）。此后，血浆葡萄糖恢复到正常血糖水平（6.0 +/- 0.3 mmol / L）。在胰岛素输注的早期阶段（15至30分钟），在达到低血糖（4.7 +/- 0.3 mmol / L）之前，激活信号未改变。但是，一旦达到降血糖平台，激活信号就会明显降低至输注前值的57 +/- 6％。大脑中未被激活的对照区域在MR信号强度方面未显示任何明显变化。回到正常血糖后，激活信号变化增加到原始水平的10％以内。在正常血糖高胰岛素钳夹实验中未观察到明显的激活变化。作者得出的结论是，由于胰岛素引起的低血糖，fMRI可以检测脑功能的变化。在fMRI激活实验中观察到的信号变化对血糖水平敏感，并且可能反映了脑代谢的增加，这受低血糖过程中底物剥夺的限制。

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