Synthesis of the A,B-ring-truncated OSW saponin analogs and their antitumor activities.

Peng W; Tang P; Hu X; Liu JO; Yu B

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Synthesis of the A,B-ring-truncated OSW saponin analogs and their antitumor activities.

机译：A，B环截断的OSW皂苷类似物的合成及其抗肿瘤活性。

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摘要

The A,B-ring-truncated OSW saponin analogs (1, 18a, and 18b) were synthesized. These greatly simplified trans-hydrindane disaccharides retained considerable inhibitory activity against the growth of HeLa and Jurkat T cells (IC(50)=0.8-21.1 microM).

机译：合成了A，B环截短的OSW皂苷类似物（1、18a和18b）。这些大大简化的反式-双氢二糖保留了相当大的抑制活性，对抗HeLa和Jurkat T细胞的生长（IC（50）= 0.8-21.1 microM）。

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《Bioorganic and Medicinal Chemistry Letters》 |2007年第20期|共4页
作者
Peng W; Tang P; Hu X; Liu JO; Yu B;
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正文语种 eng
中图分类药学;生物化学;
关键词
analogs; Synthesis; growth aspects;

机译：类似物;合成;生长方面;

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专利

1. Synthesis of the A,B-ring-truncated OSW saponin analogs and their antitumor activities. [J] . Peng W, Tang P, Hu X, Bioorganic and Medicinal Chemistry Letters . 2007,第20期

机译：A，B环截断的OSW皂苷类似物的合成及其抗肿瘤活性。
2. Synthesis of 5(6)-dihydro-OSW-1 analogs bearing three kinds of disaccharides linking at 15-hydroxy and their antitumor activities. [J] . Guan Y, Zheng D, Zhou L, Bioorganic and Medicinal Chemistry Letters . 2011,第10期

机译：5（6）-dihydro-OSW-1类似物的合成，这些类似物带有三种在15-羟基处连接的二糖及其抗肿瘤活性。
3. Synthesis of 5(6)-dihydro-OSW-1 analogs bearing three kinds of disaccharides linking at 15-hydroxy and their antitumor activities. [J] . Guan Y, Zheng D, Zhou L, Bioorganic and Medicinal Chemistry Letters . 2011,第10期

机译：5（6）-dihydro-OSW-1类似物的合成，这些类似物带有三种在15-羟基处连接的二糖及其抗肿瘤活性。
4. Chemical probe-based analysis of OSBP paralog selectivity of antitumor saponin OSW-1 [C] . Rina Komatsu, Naho Isogai, Kaori Sakurai 日本化学会春季年会講演予稿集 . 2018

机译：基于化学探针的抗肿瘤皂苷OSW-1的OSBP ParaLog选择性分析
5. 1. Design and synthesis of carbohydrate cancer vaccines based on biochemical modification of cancer cells. 2. Studies on the total synthesis of an antitumor saponin, OSW-1. [D] . Pan, Yanbin. 2005

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7. OSW Saponins: Facile Synthesis toward a New Type of Structures with Potent Antitumor Activities [O] . -1

机译：OSW Saponins：朝向具有强大抗肿瘤活动的新型结构的容易合成

Synthesis of the A,B-ring-truncated OSW saponin analogs and their antitumor activities.

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