Synthesis, characterisation and biological activities of 2-methylbenzyl 2-(dipyridin-2-yl methylene) hydrazinecarbodithioate

Ravoof T.B.S.A.; Crouse K.A.; Tahir M.I.M.; Rosli R.; Watkin D.J.; How F.N.F.

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Synthesis, characterisation and biological activities of 2-methylbenzyl 2-(dipyridin-2-yl methylene) hydrazinecarbodithioate

机译：2-（二吡啶-2-甲基亚甲基）肼基二硫代硫酸二甲酯的合成，表征和生物学活性

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A new tridentate nitrogen-sulphur Schiff base has been synthesised from the condensation of di-2-pyridylketone and a novel dithiocarbazate, S-2-methylbenzyl-dithiocarbazate (S2MBDTC). The Schiff base was characterized using various physico-chemical and spectroscopic techniques. The X-ray crystallographic analysis of the Schiff base is reported. The Schiff base crystallized in a monoclinic system with a space group of P 21, with crystal cell parameters a = 10.8128 (2) ?, b = 9.3832 (2) ?, c = 18.0352 (4) ?, β = 97.1311 (9)°. The Schiff base was found to be inactive against selected microbes and two breast cancer cell lines (MCF-7 = Human breast cancer cell line with positive estrogen receptor and MDA-MB-231 = Human breast cancer cell line with negative estrogen receptor).

机译：由二-2-吡啶基酮与新型二硫代氨基甲酸酯S-2-甲基苄基二硫代氨基甲酸酯（S2MBDTC）的缩合反应合成了一种新的三齿氮硫席夫碱。使用各种物理化学和光谱技术对席夫碱进行了表征。报道了席夫碱的X射线晶体学分析。席夫碱在单斜晶系体系中以空间群P 21 / n结晶，晶格参数a = 10.8128（2）β，b = 9.3832（2）α，c = 18.0352（4）α，β= 97.1311（ 9）°。发现席夫碱对选定的微生物和两种乳腺癌细胞系无活性（MCF-7 =雌激素受体阳性的人乳腺癌细胞系和MDA-MB-231 =雌激素受体阴性的人乳腺癌细胞系）。

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《Journal of chemical crystallography》 |2011年第4期|共5页
作者
Ravoof T.B.S.A.; Crouse K.A.; Tahir M.I.M.; Rosli R.; Watkin D.J.; How F.N.F.;
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正文语种 eng
中图分类晶体学;
关键词
Biological activity; Di-2-pyridylketone Schiff base; Dithiocarbazate;

机译：生物活性;二-2-吡啶基席夫碱;二硫代氨基甲酸酯;

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Synthesis, characterisation and biological activities of 2-methylbenzyl 2-(dipyridin-2-yl methylene) hydrazinecarbodithioate

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