DNA binding and cleavage studies of dichlorido [bis(2-ethyl-5-methyl-1H- imidazol-4-yl-kN ~3)methane]cobalt(II) monohydrate

Qian Z.; Qihe G.; Yanghui L.; Xiaomin Q.; Jian X.; Baiwang S.

首页> 外文期刊>Journal of chemical crystallography >DNA binding and cleavage studies of dichlorido [bis(2-ethyl-5-methyl-1H- imidazol-4-yl-kN ~3)methane]cobalt(II) monohydrate

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DNA binding and cleavage studies of dichlorido [bis(2-ethyl-5-methyl-1H- imidazol-4-yl-kN ~3)methane]cobalt(II) monohydrate

机译：一水合二水合[双（2-乙基-5-甲基-1H-咪唑-4-基-kN〜3）甲烷]甲烷的DNA结合和裂解研究

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The synthesized complex [Co(L) _2Cl _2H _2O] (L = 5,5'-bis(2-ethyl-4-methylimidazol)methane) crystallizes in the monoclinic system, space group P2(1)/m, with a = 8.3927(7), b = 12.1388(14), c = 8.5860(9) ?, α = 90.00, β = 97.0450(10), γ = 90.00°, Z = 2, R _1 = 0.0420, wR _2 = 0.1018. The Co(II) lies on a mirror plane and displays a tetrahedral coordination with two N atoms of the imidazole ligand and two Cl atoms. The asymmetric unit also contains a solvate water molecule. The terminal C-atom of the ethyl group was disordered over two sites C6 and C6' with equal site occupancy factors. The interaction of the complex with calf thymus DNA has been studied using emission spectroscopy, circular dichroism and gel electrophoresis measurements. The results indicate that the title complex binds to double-stranded DNA through partial intercalation and can cleave DNA.

机译：合成的复合物[Co（L）_2Cl _2H _2O]（L = 5,5'-双（2-乙基-4-甲基咪唑）甲烷）在单斜晶系空间群P2（1）/ m中结晶，其中a = 8.3927（7），b ＝ 12.1388（14），c ＝ 8.5860（9），α＝ 90.00，β＝ 97.0450（10），γ＝ 90.00°，Z ＝ 2，R_1 ＝ 0.0420，wR_2 ＝ 0.1018。 Co（II）位于镜平面上，并与咪唑配体的两个N原子和两个Cl原子显示四面体配位。不对称单元还包含溶剂化水分子。乙基的末端C原子在两个位点C6和C6'上以相同的位点占用因子无序排列。使用发射光谱，圆二色性和凝胶电泳测量研究了复合物与小牛胸腺DNA的相互作用。结果表明标题复合物通过部分插入与双链DNA结合并且可以切割DNA。

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《Journal of chemical crystallography》 |2012年第5期|共4页
作者
Qian Z.; Qihe G.; Yanghui L.; Xiaomin Q.; Jian X.; Baiwang S.;
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正文语种 eng
中图分类晶体学;
关键词
Binding mode; Calf thymus DNA; Cobalt(II) complex; Crystal structure;

机译：结合方式;小胸腺DNA;钴（II）配合物;晶体结构;

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1. DNA binding and cleavage studies of dichlorido [bis(2-ethyl-5-methyl-1H- imidazol-4-yl-kN ~3)methane]cobalt(II) monohydrate [J] . Qian Z., Qihe G., Yanghui L., Journal of chemical crystallography . 2012,第5期

机译：一水合二水合[双（2-乙基-5-甲基-1H-咪唑-4-基-kN〜3）甲烷]甲烷的DNA结合和裂解研究
2. Dichlorido[bis(2-ethyl-5-methyl-1H-imidazol-4-yl-κN3)methane]cobalt(II) monohydrate [J] . Gao G., Li J.-F., Luo Y.-H., Acta Crystallographica Section E: Crystallographic Communications . 2011,第5期

机译：一水合二氯二[二（2-乙基-5-甲基-1H-咪唑-4-基-κN3）甲烷]钴（II）
3. Dichlorido[bis(2-ethyl-5-methyl-1H-imidazol-4-yl-κN3)methane]cobalt(II) monohydrate [J] . Gao G., Li J.-F., Luo Y.-H., Acta Crystallographica Section E: Crystallographic Communications . 2011,第5期

机译：一水合二氯二[二（2-乙基-5-甲基-1H-咪唑-4-基-κN3）甲烷]钴（II）
4. Conversion Of Helix-turn-helix Motif Sequence-specific DNA Binding Proteins Into Site-specific DNA Cleavage Agents [C] . Ebright R.H., Ebright Y.W., Pendergrast P.S., Engineering in Medicine and Biology Society, 1990., Proceedings of the Twelfth Annual International Conference of the IEEE . 1990

机译：螺旋转螺旋基序序列特定的DNA结合蛋白到位点特异性DNA裂解剂的转换。
5. Non-random double strand cleavage of DNA by a monofunctional metal complex: Binding, mechanistic, and molecular recognition studies of ((2S,8R)-5-amino-2,8-dibenzyl-5-methyl-3,7-diazanonanedioate)copper(II). [D] . Detmer, Charles Anthony, III. 1998

机译：单功能金属络合物对DNA的非随机双链裂解：（（2S，8R）-5-氨基-2,8-二苄基-5-甲基-3,7-二氮杂壬二酸酯）的结合，机理和分子识别研究铜（II）。
6. DNA-Binding Study of Tetraaqua-bis(p-nitrobenzoato)cobalt(II) Dihydrate Complex: Co(H2O)4(p-NO2C6H4COO)2·2H2O [O] . Ali Arslantas, A. Kadir Devrim, Hacali Necefoglu 2007

机译：四水合双（对硝基苯甲酰基）钴（II）二水合物的DNA结合研究：Co（H2O）4（p-NO2C6H4COO）2·2H2O
7. Dichlorido[bis(2-ethyl-5-methyl-1H-imidazol-4-yl-κN3)methane]cobalt(II) monohydrate [O] . Xiao-Min Qian, Yang-Hui Luo, Jin-Feng Li, 2011

机译：一水合二氯二[二（2-乙基-5-甲基-1H-咪唑-4-基-＆＃954; N3）甲烷]钴（II）

DNA binding and cleavage studies of dichlorido [bis(2-ethyl-5-methyl-1H- imidazol-4-yl-kN ~3)methane]cobalt(II) monohydrate

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