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首页> 外文期刊>Clinical infectious diseases >Health-related quality of life and survival among HIV-infected patients receiving highly active antiretroviral therapy: a study of patients in the AIDS Therapy Evaluation in the Netherlands (ATHENA) Cohort.
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Health-related quality of life and survival among HIV-infected patients receiving highly active antiretroviral therapy: a study of patients in the AIDS Therapy Evaluation in the Netherlands (ATHENA) Cohort.

机译：在接受高活性抗逆转录病毒治疗的HIV感染患者中，健康相关的生活质量和生存：荷兰（ATHENA）队列中艾滋病治疗评估中的患者研究。

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BACKGROUND: Previous studies have shown that health-related quality of life (HRQL) predicts survival in patients infected with human immunodeficiency virus (HIV). However, these studies predated the highly active antiretroviral therapy (HAART) era, included only a few patients receiving HAART, or had a limited duration of follow-up. This study investigates whether HRQL predicts survival among HIV-infected patients receiving HAART. METHODS: HIV-infected patients participating in the focus group of the AIDS Therapy Evaluation in the Netherlands (ATHENA) study and starting or already receiving HAART completed the Medical Outcomes Study HIV Health Survey at study entry (1 May 1998 through 31 December 2000). The physical health summary (PHS) and mental health summary (MHS) scores were calculated. All-cause mortality was established at 31 March 2008. Kaplan-Meier analysis and Cox regression models were performed to predict survival. RESULTS: The median follow-up was 8.4 years. Sixty-six patients (11.8%) died during follow-up. We found a significant relation between quartiles of PHS and survival (P < .001, log-rank test). Of patients with a PHS, 26 (20%) died in quartile 1 (indicating worst HRQL), 17 (13%) died in quartile 2, 10 (8%) died in quartile 3, and 5 (4%) died in quartile 4 (indicating best HRQL) (P< .001). The prediction of PHS on survival was independent of other (clinical) parameters (P< .001). No relation was found between MHS and survival (P= .13). CONCLUSION: Patient-reported HRQL predicted survival among HIV-infected patients receiving HAART. This information could be highly useful for physicians in determining the prognosis of their patients.
机译：背景：以前的研究表明，与健康相关的生活质量（HRQL）可以预测感染了人类免疫缺陷病毒（HIV）的患者的存活率。但是，这些研究早于高活性抗逆转录病毒疗法（HAART）时代，仅包括接受HAART的少数患者，或随访时间有限。这项研究调查了HRQL是否可以预测接受HAART的HIV感染患者的生存。方法：参加荷兰艾滋病治疗评估（ATHENA）研究重点小组并开始或已经接受HAART的HIV感染患者在研究进入时（1998年5月1日至2000年12月31日）完成了医学结果研究HIV健康调查。计算身体健康摘要（PHS）和精神健康摘要（MHS）分数。于2008年3月31日确定了全因死亡率。进行了Kaplan-Meier分析和Cox回归模型以预测存活率。结果：中位随访时间为8.4年。随访期间有66例患者（11.8％）死亡。我们发现PHS的四分位数与生存率之间存在显着关系（P <.001，对数秩检验）。在PHS患者中，四分位1死亡26位（20％）（表明HRQL最差），四分位2死亡17位（13％），四分位3死亡10位（8％），四分位5位死亡（4％） 4（表示最佳HRQL）（P <.001）。 PHS存活率的预测与其他（临床）参数无关（P <.001）。在MHS与生存率之间未发现任何相关性（P = 0.13）。结论：患者报告的HRQL预测接受HAART的HIV感染患者的生存率。该信息对于医生确定患者的预后可能非常有用。

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