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首页> 外文期刊>Clinical infectious diseases >Health-related quality of life and survival among HIV-infected patients receiving highly active antiretroviral therapy: a study of patients in the AIDS Therapy Evaluation in the Netherlands (ATHENA) Cohort.
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Health-related quality of life and survival among HIV-infected patients receiving highly active antiretroviral therapy: a study of patients in the AIDS Therapy Evaluation in the Netherlands (ATHENA) Cohort.

机译：艾滋病毒感染患者的健康有关的生活质量和生存率，接受高度活跃的抗逆转录病毒治疗：荷兰艾滋病治疗评估患者的研究（雅典娜）队列。

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BACKGROUND: Previous studies have shown that health-related quality of life (HRQL) predicts survival in patients infected with human immunodeficiency virus (HIV). However, these studies predated the highly active antiretroviral therapy (HAART) era, included only a few patients receiving HAART, or had a limited duration of follow-up. This study investigates whether HRQL predicts survival among HIV-infected patients receiving HAART. METHODS: HIV-infected patients participating in the focus group of the AIDS Therapy Evaluation in the Netherlands (ATHENA) study and starting or already receiving HAART completed the Medical Outcomes Study HIV Health Survey at study entry (1 May 1998 through 31 December 2000). The physical health summary (PHS) and mental health summary (MHS) scores were calculated. All-cause mortality was established at 31 March 2008. Kaplan-Meier analysis and Cox regression models were performed to predict survival. RESULTS: The median follow-up was 8.4 years. Sixty-six patients (11.8%) died during follow-up. We found a significant relation between quartiles of PHS and survival (P < .001, log-rank test). Of patients with a PHS, 26 (20%) died in quartile 1 (indicating worst HRQL), 17 (13%) died in quartile 2, 10 (8%) died in quartile 3, and 5 (4%) died in quartile 4 (indicating best HRQL) (P< .001). The prediction of PHS on survival was independent of other (clinical) parameters (P< .001). No relation was found between MHS and survival (P= .13). CONCLUSION: Patient-reported HRQL predicted survival among HIV-infected patients receiving HAART. This information could be highly useful for physicians in determining the prognosis of their patients.
机译：背景：以前的研究表明，与人类免疫缺陷病毒（HIV）感染的患者的生存有关的生命质量（HRQL）。然而，这些研究捕获了高活性的抗逆转录病毒治疗（HAART）时代，仅包括少数患者接受HAART，或者随访持续时间有限。本研究调查HRQL是否预测接受HAART的艾滋病毒感染患者的存活。方法：艾滋病毒感染患者参与荷兰艾滋病治疗评估的焦点组（athena）研究以及开始或已经接受HAART完成的医学结果研究艾滋病毒卫生调查（1998年5月31日至2000年12月31日）。计算物理健康状况（pHS）和心理健康摘要（MHS）得分。所有原因死亡率于2008年3月31日建立。考察梅尔分析和Cox回归模型进行了预测生存。结果：中位后续时间为8.4岁。在随访期间，六十六名患者（11.8％）死亡。我们在pHS和生存中的四分位数之间发现了重要的关系（P <.001，log-rank测试）。用pHS，26（20％）的患者在四分位数1（表明最差HRQ1）中死亡，17（13％）在四分位数2中死亡，10（8％）在四分位数3中死亡，5（4％）在四分位数死亡4（表示最佳HRQL）（P <.001）。对存活的pHS的预测与其他（临床）参数（p <.001）无关。 MHS和生存之间没有发现任何关系（P = .13）。结论：患者报告的HRQL预测接受HAART的艾滋病毒感染患者的存活。这些信息对于确定患者预后的医生来说非常有用。

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