Synthesis and purine receptor affinity of 6-oxopurine nucleosides and nucleotides containing (N)-methanocarba-pseudoribose rings.

Ravi G; Lee K; Ji X; Kim HS; Soltysiak KA; Marquez VE; Jacobson KA

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Synthesis and purine receptor affinity of 6-oxopurine nucleosides and nucleotides containing (N)-methanocarba-pseudoribose rings.

机译：6-氧代嘌呤核苷和含有（N）-甲氨基甲酰基-伪核糖环的核苷酸的合成及其嘌呤受体亲和力。

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6-Oxopurine derivatives containing a northern (N) methanocarba modification (i.e., fused cyclopropane and cyclopentane rings in place of the ribose) were synthesized and the adenosine receptor affinity measured. Guanine or hypoxanthine was coupled at the 7-position, or 1,3-dibutylxanthine was coupled at the 9-position. The pseudoribose ring was also substituted at the 5'-position with an N-methyluronamide or with phosphate groups.

机译：合成了具有北部（N）甲氧羰基修饰的6-氧代嘌呤衍生物（即取代核糖的稠合的环丙烷和环戊烷环），并测量了腺苷受体亲和力。鸟嘌呤或次黄嘌呤在7位偶联，或1，3-二丁基黄嘌呤在9位偶联。伪核糖环还在5'-位被N-甲基脲酰胺或磷酸基团取代。

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来源
《Bioorganic and Medicinal Chemistry Letters》 |2001年第17期|共6页
作者
Ravi G; Lee K; Ji X; Kim HS; Soltysiak KA; Marquez VE; Jacobson KA;
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正文语种 eng
中图分类药学;生物化学;
关键词
Containing; Ring; Position;

机译：包含;环;位置;

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专利

1. Synthesis and purine receptor affinity of 6-oxopurine nucleosides and nucleotides containing (N)-methanocarba-pseudoribose rings. [J] . Ravi G, Lee K, Ji X, Bioorganic and Medicinal Chemistry Letters . 2001,第17期

机译：6-氧代嘌呤核苷和含有（N）-甲氨基甲酰基-伪核糖环的核苷酸的合成及其嘌呤受体亲和力。
2. Synthesis of 8-amino and 8-substituted amino derivatives of acyclic purine nucleoside and nucleotide analogs. Alkylation of 8-substituted purine bases. [J] . Janeba Z, Holy A Nucleosides, nucleotides and nucleic acids . 2001,第4a7期

机译：无环嘌呤核苷和核苷酸类似物的8-氨基和8-取代的氨基衍生物的合成。 8-取代的嘌呤碱的烷基化。
3. A new synthesis of 5′-deoxy-8,5′-cyclo-adenosine and -inosine: conformationally-fixed purine nucleosides (nucleosides and nucleotides XVI) [J] . Akira Matsuda, Kei Muneyama, Takako Nishida, Nucleic acids research . 1976,第12期

机译：5'-脱氧-8,5'-环腺苷和-肌苷的新合成：构象固定的嘌呤核苷（核苷和核苷酸XVI）
4. Analysis of Purine and Pyrimidine Bases, Nucleosides, and Nucleotides in Protein Hydrolysates [C] . Damon C. Barbacci, Kemberly Patteson, Shannon Koontz, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：丙烯和嘧啶碱基，核苷和蛋白质水解产物中的核苷酸分析
5. From nucleosides and nucleotides to DNA: Synthesis, enzymatic study and structural analysis of oxidized lesions beyond 8-oxo-purine [D] . Ye, Yu 2007

机译：从核苷和核苷酸到DNA：8-氧代嘌呤以外的氧化损伤的合成，酶学研究和结构分析
6. Synthesis and Purine Receptor Affinity of 6-Oxopurine Nucleosides and Nucleotides Containing (N)-Methanocarba-pseudoribose Rings [O] . Gnana Ravi, Kyeong Lee, Xiao-duo Ji, -1

机译：6-氧嘌呤核苷和含（N）-甲氨基甲氨基磺酸-伪核糖环的核苷酸的合成和嘌呤受体亲和力
7. Studies of nucleosides and nucleotides. LXVIII. Purine cyclonucleosides. 29. Synthesis and properties of O-cyclonucleosides derived from hyposanthine, mercaptopurine, methylmercaptopurine and purine. [O] . MORIO IKEHARA, MASAKO MURAOKA 1976

机译：核苷和核苷酸的研究。 lxviii。嘌呤环核苷。 29.衍生自过黄嘌呤，巯基嘌呤，甲基汞和嘌呤的O-环核苷的合成和性质。
8. Synthesis of Purine Nucleoside and Nucleotide Analogs as Antiparasitic Agents [R] . Neenan, J. P. 1979

机译：嘌呤核苷和核苷酸类似物作为抗寄生虫剂的合成

Synthesis and purine receptor affinity of 6-oxopurine nucleosides and nucleotides containing (N)-methanocarba-pseudoribose rings.

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