Key features of the EXPANSE clinical program for apixaban in the prevention and treatment of thrombotic disorders

Nadia Rosencher; Paul Zufferey; Silvy Laporte; Patrick Mismetti

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Key features of the EXPANSE clinical program for apixaban in the prevention and treatment of thrombotic disorders

机译：阿哌沙班EXPANSE临床计划在预防和治疗血栓形成性疾病中的关键特征

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Apixaban is a new oral selective factor Xa inhibitor. Its efficacy and safety are being investigated in a large clinical development program across various indications in venous and arterial thrombotic disorders. A twice-daily regimen was chosen for all the studied indications of apixaban. All three Phase III studies in the prevention of venous thromboembolism after total hip or knee replacement (ADVANCE-1, -2 and -3) have been completed. On the basis of the data obtained so far, apixaban appears to be a promising new drug for the management of thrombotic diseases.

机译：阿哌沙班是一种新型的口服选择因子Xa抑制剂。在大型临床开发计划中，正在对各种适应症进行静脉和动脉血栓形成疾病的研究，以评估其功效和安全性。为研究阿哌沙班的所有适应症选择每天两次的治疗方案。在全部髋关节或膝关节置换术后（ADVANCE-1，-2和-3）预防静脉血栓栓塞的所有三项III期研究均已完成。根据迄今为止获得的数据，阿哌沙班似乎是用于治疗血栓性疾病的有前途的新药。

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《Clinical investigation》 |2011年第5期|共13页
作者
Nadia Rosencher; Paul Zufferey; Silvy Laporte; Patrick Mismetti;
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正文语种 eng
中图分类预防医学、卫生学;
关键词
anticoagulant; apixaban; arterial thrombosis; atrial fibrillation; bleeding; factor Xa; oral; orthopedic surgery; thrombosis; venous thromboembolism;

机译：抗凝剂;阿哌沙班;动脉血栓形成;心房纤颤;出血;Xa因子;口服;骨科手术;血栓形成;静脉血栓栓塞;

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1. Key features of the EXPANSE clinical program for apixaban in the prevention and treatment of thrombotic disorders [J] . Nadia Rosencher, Paul Zufferey, Silvy Laporte, Clinical investigation . 2011,第5期

机译：阿哌沙班EXPANSE临床计划在预防和治疗血栓形成性疾病中的关键特征
2. Re: 'Efficacy and Safety of the New Oral Anticoagulants Dabigatran, Rivaroxaban, Apixaban, and Edoxaban in the Treatment and Secondary Prevention of Venous Thromboembolism: A Systematic Review and Meta-analysis of Phase III Trials'- Key Learning Points for Surgeons [J] . Hurst K. V., Lee R., Milosevic I., European journal of vascular and endovascular surgery: the official journal of the European Society for Vascular Surgery . 2015,第1期

机译：回复：“新型口服抗凝药达比加群，利伐沙班，阿哌沙班和埃多沙班在静脉血栓栓塞的治疗和二级预防中的功效和安全性：III期临床试验的系统评价和荟萃分析”-外科医生的主要学习重点
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4. Characterization of Physicians Workload in a Reference Center for the Treatment of Thrombotic and Bleeding Disorders ^* [C] . S. Rosati, F. Valeri, A. Borchiellini, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2019

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Key features of the EXPANSE clinical program for apixaban in the prevention and treatment of thrombotic disorders

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