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首页> 外文期刊>Journal of clinical psychopharmacology >Serotonin-selective reuptake inhibitors and nonsteroidal anti-inflammatory drugs-important considerations of adverse interactions especially for the treatment of myalgic encephalomyelitis/chronic fatigue syndrome.
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Serotonin-selective reuptake inhibitors and nonsteroidal anti-inflammatory drugs-important considerations of adverse interactions especially for the treatment of myalgic encephalomyelitis/chronic fatigue syndrome.

机译：血清素选择性再摄取抑制剂和非甾体类抗炎药-不良相互作用的重要考虑因素，尤其是在治疗肌性脑脊髓炎/慢性疲劳综合征时。

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Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) affects as many as 1 in 100 women in the United States, but its pathogenesis remains largely unknown. ME/CFS is associated with depression, inability to concentrate (brain fog), and pain, necessitating the concurrent use of antidepressants, especially serotonin-selective reuptake inhibitors (SSRIs) and nonsteroidal anti-inflammatory drugs (NSAIDs). Considerable evidence, however, suggests that the older tri-. cyclic antidepressants (TCAs) may be more efficacious than SSRIs in ME/CFS and in fibro-myalgia.12'13 Moreover, TCAs are also effective in managing chronic pain. Evidence presented in this issue further indicates that TCAs can also inhibit activation of mast cells. These unique immune cells that are found in all tissues, but also especially in the diencephalon, were hypothesized to be involved in ME/CFS.
机译：肌病性脑脊髓炎/慢性疲劳综合症（ME / CFS）在美国影响多达100名女性中的1名，但其发病机理仍然未知。 ME / CFS与抑郁症，精神不集中（脑雾）和疼痛有关，因此必须同时使用抗抑郁药，尤其是血清素选择性再摄取抑制剂（SSRIs）和非甾体抗炎药（NSAIDs）。然而，大量证据表明，较老的三。环状抗抑郁药（TCA）在ME / CFS和纤维肌痛中可能比SSRI更有效。12'13此外，TCA在治疗慢性疼痛方面也很有效。本期的证据进一步表明，TCA还可以抑制肥大细胞的活化。在所有组织中，尤其是在双脑中发现的这些独特的免疫细胞被认为与ME / CFS有关。

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